Anti-CD103抗体[2E7] (ab25198)
Key features and details
- Armenian hamster monoclonal [2E7] to CD103
- Suitable for: IHC-Fr, IP, Cellular Activation, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG
Related conjugates and formulations
概述
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产品名称
Anti-CD103抗体[2E7]
参阅全部 CD103 一抗 -
描述
亚美尼亚仓鼠单克隆抗体[2E7] to CD103 -
宿主
Armenian hamster -
经测试应用
适用于: IHC-Fr, IP, Cellular Activation, Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Tissue, cells or virus corresponding to CD103. C57BL/6J mouse intestinal intraepithelial lymphocytes (IEL)
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常规说明
This antibody is reported to have signal inducing activity in a redirected lysis assay and to co stimulate IEL and CD8+ lymph node cells in conjunction with anti TCR in vitro, which runs counter to the usual inhibition of CTL by anti integrins. The property of costimulation is not unique to the mouse since the combination of anti human alpha IEL (intraepithelial lymphocytes) plus anti TCR will produce similar proliferation in human cells, with the exception that CD8+ cells are not stimulated.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 8.20
Constituents: 0.95% Sodium borate, 0.6% Boric Acid -
Concentration information loading... -
纯度
Affinity purified -
Primary antibody说明
This antibody is reported to have signal inducing activity in a redirected lysis assay and to co stimulate IEL and CD8+ lymph node cells in conjunction with anti TCR in vitro, which runs counter to the usual inhibition of CTL by anti integrins. The property of costimulation is not unique to the mouse since the combination of anti human alpha IEL (intraepithelial lymphocytes) plus anti TCR will produce similar proliferation in human cells, with the exception that CD8+ cells are not stimulated. -
克隆
单克隆 -
克隆编号
2E7 -
同种型
IgG -
轻链类型
kappa -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab25198于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
|
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| Cellular Activation |
Use at an assay dependent concentration.
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| Flow Cyt |
Use at an assay dependent concentration.
ab18479 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody. |
| 说明 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
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IP
Use at an assay dependent concentration. |
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Cellular Activation
Use at an assay dependent concentration. |
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Flow Cyt
Use at an assay dependent concentration. ab18479 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. -
组织特异性
Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells. -
序列相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
结构域
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 16407 Mouse
- SwissProt: Q60677 Mouse
- Unigene: 96 Mouse
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别名
- A530055J10 antibody
- alpha-E1 antibody
- alpha-M290 antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab25198 被引用在 1 文献中.
- Zhou J et al. Prognostic and therapeutic value of CD103+ cells in renal cell carcinoma. Exp Ther Med 15:4979-4986 (2018). PubMed: 29805521