Anti-CCM2抗体(ab129386)
Key features and details
- Rabbit polyclonal to CCM2
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CCM2抗体
参阅全部 CCM2 一抗 -
描述
兔多克隆抗体to CCM2 -
宿主
Rabbit -
经测试应用
适用于: WB, ICC/IFmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein (His-tag) corresponding to Human CCM2 aa 1-444.
Database link: Q9BSQ5 -
阳性对照
- ICC/IF: Human foreskin tissue
WB: CCM2 overexpressed in C0S1 cells
- ICC/IF: Human foreskin tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
纯化说明
Endotoxin level: <0.1 EU/1µg of ab129386 (LAL) -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab129386于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 49 kDa.
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ICC/IF |
1/200.
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说明 |
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WB
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 49 kDa. |
ICC/IF
1/200. |
靶标
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功能
May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock. -
疾病相关
Defects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2) [MIM:603284]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. -
序列相似性
Contains 1 PID domain. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 83605 Human
- Omim: 607929 Human
- SwissProt: Q9BSQ5 Human
- Unigene: 148272 Human
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别名
- C7orf22 antibody
- Ccm2 antibody
- CCM2 gene antibody
see all
图片
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All lanes : Anti-CCM2 antibody (ab129386) at 5 µg/ml
Lane 1 : Mwt marker
Lane 2 : CCM2 knockout
Lane 3 : CCM2 wildtype
Lane 4 : CCM2 overexpressed in C0S1 cells
Predicted band size: 49 kDa -
All lanes : Anti-CCM2 antibody (ab129386) at 5 µg/ml
Lane 1 : Mwt marker
Lane 2 : CCM2 knockout
Lane 3 : CCM2 wildtype
Lane 4 : CCM2 overexpressed in C0S1 cells
Predicted band size: 49 kDa -
ab129386, at a 1/50 dilution, staining CCM2 (green) in a cryo-section of unfixed Human foreskin tissue by Immunofluorescence.
A) Note specific staining in the wall of microvessels.
B) Negative control of a consecutive section.
Note non-specific fluorescence in elastic fibres in the adventitia of an arteriol.
Nuclei counter-stained with Dapi (blue).
实验方案
数据表及文件
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Datasheet download
文献 (0)
ab129386 尚未被引用在任何文献中。