Anti-CCDC39抗体(ab122269)
Key features and details
- Rabbit polyclonal to CCDC39
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CCDC39抗体 -
描述
兔多克隆抗体to CCDC39 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment corresponding to Human CCDC39 aa 191-288.
Sequence:ILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGD IDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADR
Database link: Q9UFE4 -
阳性对照
- RT-4 lysate, Human pancreas tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab122269于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 0.04 - 0.4 µg/ml.
|
|
| IHC-P |
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
|
| 说明 |
|---|
|
WB
Use a concentration of 0.04 - 0.4 µg/ml. |
|
IHC-P
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly. -
组织特异性
Mainly expressed in nasal brushings and, to a lesser extent, in lungs and testis. -
疾病相关
Defects in CCDC39 are the cause of primary ciliary dyskinesia type 14 (CILD14) [MIM:613807]. A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. -
序列相似性
Belongs to the CCDC39 family. -
细胞定位
Cytoplasm > cytoskeleton > cilium axoneme. CCDC40 is required for localization to axonemes. - Information by UniProt
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数据库链接
- Entrez Gene: 339829 Human
- Omim: 613798 Human
- SwissProt: Q9UFE4 Human
- Unigene: 712820 Human
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别名
- CCD39_HUMAN antibody
- Ccdc39 antibody
- CILD141 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCDC39 antibody (ab122269)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human bronchus tissue labelling CCDC39 with ab122269. Staining shows strong positivity in cilia of respiratory epithelial cells.
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Western blot - Anti-CCDC39 antibody (ab122269)All lanes : Anti-CCDC39 antibody (ab122269) at 1/250 dilution
Lane 1 : RT-4 lysate
Lane 2 : U251-MG lysate
Lane 3 : Human plasma lysate
Lane 4 : Human liver lysate
Lane 5 : Human tonsil lysate
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab122269 尚未被引用在任何文献中。