Anti-Caveolin-2抗体(ab2911)
Key features and details
- Rabbit polyclonal to Caveolin-2
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Caveolin-2抗体
参阅全部 Caveolin-2 一抗 -
描述
兔多克隆抗体to Caveolin-2 -
宿主
Rabbit -
特异性
Detects caveolin-2 from rat tissues. This antibody does not detect caveolin-1 or -3. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Rat
预测可用于: Sheep, Rabbit, Cow, Cat, Human, Pig, Chimpanzee, Gorilla, African green monkey, African bush elephant
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免疫原
Synthetic peptide corresponding to Rat Caveolin-2 aa 1-100.
Database link: Q2IBC5 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (2) |
Use at an assay dependent concentration.
Can be blocked with Caveolin-2 peptide. |
| 说明 |
|---|
|
WB
Use at an assay dependent concentration. Can be blocked with Caveolin-2 peptide. |
靶标
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功能
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression. -
组织特异性
Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts. -
序列相似性
Belongs to the caveolin family. -
翻译后修饰
Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin. -
细胞定位
Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane. Membrane > caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. - Information by UniProt
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数据库链接
- Entrez Gene: 858 Human
- Entrez Gene: 12390 Mouse
- Entrez Gene: 100362824 Rat
- Entrez Gene: 363425 Rat
- Omim: 601048 Human
- SwissProt: P51636 Human
- SwissProt: Q9WVC3 Mouse
- SwissProt: Q2IBC5 Rat
see all -
别名
- CAV antibody
- CAV2 antibody
- CAV2_HUMAN antibody
see all
图片
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Western blot - Anti-Caveolin-2 antibody (ab2911)
Western blot of caveolin-2 on rat skeletal muscle protein extract using ab2911.
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Western blot - Anti-Caveolin-2 antibody (ab2911)All lanes : Anti-Caveolin-2 antibody (ab2911) at 2 µg/ml
Lane 1 : 3T3-L1 lysate
Lane 2 : 3T3-L1 differentiated to adipocytes
Lane 3 : Mouse Heart lysate
Lane 4 : Mouse Lung lysate
Lane 5 : Mouse Adipose lysate
Lane 6 : Mouse Spleen lysate
Secondary
All lanes : Goat anti-Rabbit IgG (H+L) Superclonal Recombinant Secondary Antibody, HRP at 1/4000 dilution
数据表及文件
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SDS download
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Datasheet download
文献 (11)
ab2911 被引用在 11 文献中.
- Russell JS et al. Cardiomyoblast caveolin expression: Effects of simulated diabetes, a-linolenic acid and cell signaling pathways. Am J Physiol Cell Physiol N/A:N/A (2020). PubMed: 32348174
- Jiao F et al. Caveolin-2 is regulated by BRD4 and contributes to cell growth in pancreatic cancer. Cancer Cell Int 20:55 (2020). PubMed: 32099528
- Yang X et al. Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-ß pathway. Signal Transduct Target Ther 5:75 (2020). PubMed: 32499481
- Mortensen OV et al. MAP Kinase Phosphatase 3 (MKP3) Preserves Norepinephrine Transporter Activity by Modulating ERK1/2 Kinase-Mediated Gene Expression. Front Cell Neurosci 11:253 (2017). PubMed: 28878626
- Hoeke L et al. Intestinal Salmonella typhimurium infection leads to miR-29a induced caveolin 2 regulation. PLoS One 8:e67300 (2013). WB . PubMed: 23826261