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AB2911

Anti-Caveolin-2抗体

Anti-Caveolin-2 antibody

4

(4 Reviews)

|

(13 Publications)

Rabbit Polyclonal Caveolin-2 antibody. Suitable for WB and reacts with Rat, Mouse samples. Cited in 13 publications. Immunogen corresponding to Synthetic Peptide within Rat Cav2 aa 1-50.

查看别名

Caveolin-2, Cav2

2 Images
Western blot - Anti-Caveolin-2 antibody (AB2911)
  • WB

Unknown

Western blot - Anti-Caveolin-2 antibody (AB2911)

Western blot of caveolin-2 on rat skeletal muscle protein extract using ab2911.

All lanes:

Western blot - Anti-Caveolin-2 antibody (ab2911)

Predicted band size: 18 kDa

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Western blot - Anti-Caveolin-2 antibody (AB2911)
  • WB

Supplier Data

Western blot - Anti-Caveolin-2 antibody (AB2911)

All lanes:

Western blot - Anti-Caveolin-2 antibody (ab2911) at 2 µg/mL

Lane 1:

3T3-L1 lysate

Lane 2:

3T3-L1 differentiated to adipocytes

Lane 3:

Mouse Heart lysate

Lane 4:

Mouse Lung lysate

Lane 5:

Mouse Adipose lysate

Lane 6:

Mouse Spleen lysate

Secondary

All lanes:

Goat anti-Rabbit IgG (H+L) Superclonal Recombinant Secondary Antibody, HRP at 1/4000 dilution

Predicted band size: 18 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Rat, Mouse

应用

WB

applications

免疫原

Synthetic Peptide within Rat Cav2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q2IBC5

特异性

Detects caveolin-2 from rat tissues. This antibody does not detect caveolin-1 or -3.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>Can be blocked with Caveolin-2 peptide.</p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>Can be blocked with Caveolin-2 peptide.</p>" }, "African bush elephant": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
Preservative: 0.05% Sodium azide Constituents: PBS, 0.1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Caveolin-2 often referred to as CAV2 is a 20-22 kDa integral membrane protein and an important component of caveolae small invaginations in the plasma membrane. It is mainly expressed in adipocytes endothelial cells pneumocytes and some smooth muscle cells. CAV2 works together with other caveolins primarily caveolin-1 to form these flask-shaped invaginations which play roles in various cellular processes.
Biological function summary

Caveolin-2 participates in modulating cellular functions such as signal transduction cholesterol homeostasis and endocytosis. As part of the caveolae complex it cooperates with caveolin-1 to regulate lipid raft domains influencing the movement and function of molecules within the cell. The presence of caveolin-2 helps maintain the caveolae structure and is involved in cellular responses to mechanical stress.

Pathways

Caveolin-2 is implicated in the regulation of insulin signaling and the Ras-MAPK signaling pathway. In the insulin signaling pathway it forms complexes with caveolin-1 and other proteins like IRS-1 affecting glucose uptake in cells. In the Ras-MAPK pathway caveolin-2 interacts with signaling molecules associated with the pathway modulating cell proliferation and survival.

Caveolin-2 has been linked to cancer development and pulmonary disorders. Its interactions with caveolin-1 and other signaling proteins in cancer cells can influence tumor growth and metastasis. Additionally altered expression of caveolin-2 affects pulmonary disorders such as emphysema by impacting endothelial cell function. Understanding these connections helps in exploring potential therapeutic interventions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
See full target information Caveolin-2
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文献 (13)

Recent publications for all applications. Explore the full list and refine your search

Cancers 17: PubMed39857963

2025

Location and Movement of the Oxytocin Receptor Differ Between the Normal and Diseased Prostate.

Applications

Unspecified application

Species

Unspecified reactive species

Maree Gould,Daniil Potapov,Helen Nicholson

Journal of molecular histology 54:67-75 PubMed36719565

2023

Effects of periodic mechanical stress on cytoskeleton dependent lipid raft-induced integrin ɑ1 activation in rat nucleus pulposus cells.

Applications

Unspecified application

Species

Unspecified reactive species

Gongming Gao,Kewei Ren,Liang Chen,Xinru Li,Zitong Li,Yang Liu,Chenxi Ouyang,Hao Wang,Luming Nong,Hua Xie

Signal transduction and targeted therapy 5:75 PubMed32499481

2020

Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-β pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxue Yang,Liping Ma,Rong Wei,Tinghong Ye,JianKang Zhou,Maoyao Wen,Ruoting Men,Rami I Aqeilan,Yong Peng,Li Yang

American journal of physiology. Cell physiology : PubMed32348174

2020

Cardiomyoblast caveolin expression: Effects of simulated diabetes, α-linolenic acid and cell signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Jake S Russell,Tia A Griffith,Jason N Peart,John P Headrick

Cancer cell international 20:55 PubMed32099528

2020

Caveolin-2 is regulated by BRD4 and contributes to cell growth in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Jiao,Ting Han,Cuncun Yuan,Yiyi Liang,Jiujie Cui,Meng Zhuo,Liwei Wang

Frontiers in cellular neuroscience 11:253 PubMed28878626

2017

MAP Kinase Phosphatase 3 (MKP3) Preserves Norepinephrine Transporter Activity by Modulating ERK1/2 Kinase-Mediated Gene Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Ole V Mortensen,Mads B Larsen,Susan G Amara

PloS one 8:e67300 PubMed23826261

2013

Intestinal Salmonella typhimurium infection leads to miR-29a induced caveolin 2 regulation.

Applications

WB

Species

Unspecified reactive species

Lena Hoeke,Jutta Sharbati,Kamlesh Pawar,Andreas Keller,Ralf Einspanier,Soroush Sharbati

Experimental cell research 316:3182-96 PubMed20828556

2010

Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Linda Källquist,Hanna Rosén,Pontus Nordenfelt,Jero Calafat,Hans Janssen,Ann-Maj Persson,Markus Hansson,Inge Olsson

Canadian journal of physiology and pharmacology 88:73-6 PubMed20130741

2010

Caveolin-1 exists and may function in cardiomyocytes.

Applications

IHC-P

Species

Mouse

Woo Jung Cho,Ava K Chow,Richard Schulz,Edwin E Daniel

The Journal of biological chemistry 284:9955-64 PubMed19211560

2009

Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa.

Applications

WB

Species

Mouse

David W Zaas,Zachary D Swan,Bethany J Brown,Guojie Li,Scott H Randell,Simone Degan,Mary E Sunday,Jo Rae Wright,Soman N Abraham
View all publications
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替代产品

Primary Antibodies

AB133484

Anti-Caveolin-2 antibody [EPR5471]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Caveolin-2 antibody [EPR5471] (AB133484)

  • 2
  • 1
Primary Antibodies

AB97476

Anti-Caveolin-2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caveolin-2 antibody (AB97476)

  • 0
  • 0
Primary Antibodies

AB3417

Anti-Caveolin-2 (phospho Y19) antibody

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-Caveolin-2 (phospho Y19) antibody (AB3417)

  • 4
  • 4
Primary Antibodies

AB76405

Anti-Caveolin-2 (phospho Y27) antibody [EP2221Y]

RabMAb

Western blot - Anti-Caveolin-2 (phospho Y27) antibody [EP2221Y] (AB76405)

  • 0
  • 0
Primary Antibodies

AB79397

Anti-Caveolin-2 antibody [EPR2220] - Caveolae Marker

RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Caveolin-2 antibody [EPR2220] - Caveolae Marker (AB79397)

  • 0
  • 0

搭配使用产品

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB8227

Anti-beta Actin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-beta Actin antibody - Loading Control (AB8227)

  • 5
  • 104
Primary Antibodies

AB52894

Anti-EGFR antibody [EP38Y]

BOND RX™ Validated|KO Validated|RabMAb|Lab Essentials|20ul selling size|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFR antibody [EP38Y] (AB52894)

  • 5
  • 24
Primary Antibodies

AB32577

Anti-Caveolin-1 antibody [E249] - Caveolae Marker

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caveolin-1 antibody [E249] - Caveolae Marker (AB32577)

  • 5
  • 2

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