Anti-Cannabinoid Receptor I抗体(ab3558)
Key features and details
- Rabbit polyclonal to Cannabinoid Receptor I
- Suitable for: IP, ICC/IF, IHC-Fr, IHC-P, Flow Cyt, WB
- Reacts with: Mouse, Rat, Rabbit, Human, Ferret
- Isotype: IgG
概述
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产品名称
Anti-Cannabinoid Receptor I抗体
参阅全部 Cannabinoid Receptor I 一抗 -
描述
兔多克隆抗体to Cannabinoid Receptor I -
宿主
Rabbit -
特异性
Detects CB1 from Human and Rat tissues as well as transfected Rat CB1. -
经测试应用
适用于: IP, ICC/IF, IHC-Fr, IHC-P, Flow Cyt, WBmore details -
种属反应性
与反应: Mouse, Rat, Rabbit, Human, Ferret
预测可用于: Cat, Chimpanzee, Rhesus monkey -
免疫原
Recombinant fragment within Human Cannabinoid Receptor I aa 1-100 (N terminal). The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.1% BSA, 49% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
应用 | Ab评论 | 说明 |
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IP |
Use at an assay dependent concentration. PubMed: 22387618
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ICC/IF |
1/1000.
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IHC-Fr |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration.
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Flow Cyt |
Use at an assay dependent concentration. PubMed: 20206138
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 53 kDa.
By Western blot, this antibody detects an ~60 kDa protein representing CB1 from rat brain homogenate. |
说明 |
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IP
Use at an assay dependent concentration. PubMed: 22387618 |
ICC/IF
1/1000. |
IHC-Fr
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. PubMed: 20206138 ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
WB
Use at an assay dependent concentration. Predicted molecular weight: 53 kDa. By Western blot, this antibody detects an ~60 kDa protein representing CB1 from rat brain homogenate. |
靶标
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功能
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. -
组织特异性
Widely expressed. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 1268 Human
- Entrez Gene: 12801 Mouse
- Entrez Gene: 25248 Rat
- Omim: 114610 Human
- SwissProt: O02777 Cat
- SwissProt: Q5IS73 Chimpanzee
- SwissProt: P21554 Human
- SwissProt: P47746 Mouse
see all -
别名
- CANN6 antibody
- Cannabinoid receptor 1 antibody
- CB-R antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab3558 被引用在 5 文献中.
- Liu AN et al. The Effects of HP0044 and HP1275 Knockout Mutations on the Structure and Function of Lipopolysaccharide in Helicobacter pylori Strain 26695. Biomedicines 10:N/A (2022). PubMed: 35052824
- Wang Y et al. Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice. Int J Mol Sci 23:N/A (2022). PubMed: 35269905
- Kleyer J et al. Cannabinoid receptor trafficking in peripheral cells is dynamically regulated by a binary biochemical switch. Biochem Pharmacol 83:1393-412 (2012). Flow Cyt, IP ; Human . PubMed: 22387618
- Shen L et al. The role of peripheral cannabinoid receptors type 1 in rats with visceral hypersensitivity induced by chronic restraint stress. J Neurogastroenterol Motil 16:281-90 (2010). WB ; Rat . PubMed: 20680167
- Leonti M et al. Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochem Pharmacol 79:1815-26 (2010). WB, Flow Cyt ; Human . PubMed: 20206138