AB251766

Anti-CAMSAP2抗体

Name: CAMSAP2抗体 (ab251766)| Abcam中文官网
Brand: Abcam Limited
SKU: AB251766
Price: 5947 CNY
Availability: InStock

Anti-CAMSAP2 antibody

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(1 Publication)

Rabbit Polyclonal CAMSAP2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CAMSAP2 aa 600 to C-terminus.

查看别名

CAMSAP1L1, KIAA1078, CAMSAP2, Calmodulin-regulated spectrin-associated protein 2, Calmodulin-regulated spectrin-associated protein 1-like protein 1

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMSAP2 antibody (AB251766)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMSAP2 antibody (AB251766)

Paraffin-embedded human placenta tissue stained for CAMSAP2 using ab251766 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMSAP2 antibody (AB251766)

Paraffin-embedded human testis tissue stained for CAMSAP2 using ab251766 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMSAP2 antibody (AB251766)

Paraffin-embedded human cerebral cortex tissue stained for CAMSAP2 using ab251766 at 1/200 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-CAMSAP2 antibody (AB251766)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CAMSAP2 antibody (AB251766)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for CAMSAP2 (green) using ab251766 at 4 μg/ml in ICC/IF.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMSAP2 antibody (AB251766)

Paraffin-embedded human prostate tissue stained for CAMSAP2 using ab251766 at 1/200 dilution in immunohistochemical analysis.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human CAMSAP2 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q08AD1

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CAMSAP2 also known as calmodulin-regulated spectrin-associated protein family member 2 is a microtubule-stabilizing protein with a molecular mass of approximately 198 kDa. It binds to the minus ends of microtubules stabilizing them and regulating their dynamics. CAMSAP2 is expressed in various tissues with a significant presence in neuronal tissue. The protein plays a vital role in stabilizing the microtubule network which influences cellular architecture and intracellular transport.

Biological function summary

The regulation of microtubule dynamics by CAMSAP2 ensures proper neuronal development and function. CAMSAP2 is part of a protein complex that is essential for maintaining microtubule integrity and organization. It interacts with other proteins such as CAMSAP1 and CAMSAP3 each playing distinct roles in microtubule arrangement. These interactions help in maintaining cellular structures which are necessary for processes like cellular division and differentiation.

Pathways

CAMSAP2 is involved in microtubule-associated pathways critical for cell stability and signaling. The protein is part of the axon guidance pathway where it functions alongside other proteins including PTEN and CRMP2 to ensure correct neural network formation. CAMSAP2 also engages in the regulation of cytoskeleton organization pathways where it collaborates with microtubule-associated proteins to support cellular morphology and dynamics.

CAMSAP2 plays a part in conditions affecting the nervous system such as neurodevelopmental disorders and certain neurodegenerative diseases. Mutations or dysregulation of CAMSAP2 have been linked to intellectual disabilities due to its role in neuronal structure and signaling. This protein also interacts with tau a protein commonly associated with neurodegenerative disorders like Alzheimer's disease suggesting a potential link between CAMSAP2 function and tauopathies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

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Visit the Troubleshooting

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靶点信息

Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed : 23169647, PubMed : 24486153, PubMed : 24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed : 24486153, PubMed : 24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed : 24486153, PubMed : 24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed : 24486153, PubMed : 24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed : 27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi : together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed : 27666745). Also acts as a regulator of neuronal polarity and development : localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed : 24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed : 28726242).

See full target information CAMSAP2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of international medical research 52:3000605241282384 PubMed39628429

2024

RAB32 promotes glioma cell progression by activating the JAK/STAT3 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Sinan Zhang,Xudong Jiang,Qing Wei,Liji Huang,Zhuoyan Huang,Lina Zhang

View all publications

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Anti-CAMSAP2抗体

Anti-CAMSAP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMSAP2 antibody (AB251766)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMSAP2 antibody (AB251766)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMSAP2 antibody (AB251766)

Immunocytochemistry/ Immunofluorescence - Anti-CAMSAP2 antibody (AB251766)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMSAP2 antibody (AB251766)