重组Anti-cAMP抗体[EP8471] (ab134901)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EP8471] to cAMP
- Suitable for: ELISA, ICC/IF
- Reacts with: Species independent
Related conjugates and formulations
概述
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产品名称
Anti-cAMP抗体[EP8471]
参阅全部 cAMP 一抗 -
描述
兔单克隆抗体[EP8471] to cAMP -
宿主
Rabbit -
特异性
This antibody does not cross react with cGMP, GMP, GDP, cIMP, cCMP, or adenosine. -
经测试应用
适用于: ELISA, ICC/IFmore details -
种属反应性
与反应: Species independent -
免疫原
Chemical/ Small Molecule corresponding to cAMP conjugated to keyhole limpet haemocyanin.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EP8471 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab134901于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ELISA |
Use a concentration of 0.25 µg/ml.
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ICC/IF |
Use a concentration of 5 µg/ml.
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说明 |
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ELISA
Use a concentration of 0.25 µg/ml. |
ICC/IF
Use a concentration of 5 µg/ml. |
靶标
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相关性
Cyclic adenosine monophosphate (cAMP) plays a key role as an intracellular second messenger for transduction events that follow a number of extracellular signals. The G-Protein Coupled Receptors (GPCR) is the largest family of cell surface receptors. They can be activated by different ligands, such as neurotransmitters, hormones, ions, small molecules, peptides, and other physiological signaling molecules. Typically, the binding of the ligands to its receptor resulting in the activation of G-proteins, in return, activates the effector adenylyl cyclase evoking the production of cAMP. The activation of a protein kinase by cAMP results in the phosphorylation of substrate proteins. Currently successful drugs in marketing have been developed to target these receptors. Among the GPCRs, ~367 receptors are potential drug development targets, but only about 20 have been used to generate therapeutically and commercially successful drugs so far. Because the involvement of cAMP can amplify the response of the ligand binding, the second messenger cAMP has been largely employed to monitor the activation of the GPCR to facilitate the therapeutic drug discovery. -
细胞定位
Secreted -
别名
- 3' 5' cyclic adenosine monophosphate antibody
- Cyclic adenosine monophosphate antibody
- Cyclic AMP antibody
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab134901 被引用在 2 文献中.
- Cheng J et al. Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice. Autophagy 16:2193-2205 (2020). PubMed: 32003282
- Jiang X et al. Pinoresinol promotes MC3T3-E1 cell proliferation and differentiation via the cyclic AMP/protein kinase A signaling pathway. Mol Med Rep 20:2143-2150 (2019). PubMed: 31322181