Anti-Cadherin like 23抗体(ab131135)
Key features and details
- Rabbit polyclonal to Cadherin like 23
- Suitable for: IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-Cadherin like 23抗体 -
描述
兔多克隆抗体to Cadherin like 23 -
宿主
Rabbit -
经测试应用
适用于: IHC-P, ICC/IFmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
-
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
阳性对照
- Human spleen tissue; HeLa cells.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine), 49% PBS
PBS is without Mg2+ and Ca2+ -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab131135于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/100.
|
|
| ICC/IF |
1/100 - 1/500.
|
| 说明 |
|---|
|
IHC-P
1/100. |
|
ICC/IF
1/100 - 1/500. |
靶标
-
相关性
Cadherin like 23 (or Cadherin 23) is, like other members of the cadherin family, a calcium-dependent cell adhesion glycoprotein that preferentially interacts with itself in connecting cells. It is a single pass type I membrane protein that contains 27 cadherin domains. Cadherin like 23 is expressed in the neurosensory epithelium, where it is thought to be involved in stereocilia organisation and hair bundle formation. Defects in the gene encoding Cadherin like 23 are a cause of Usher syndrome, which is characterised by profound congenital sensorineural deafness and eventual blindness. Mutations in this gene are also a cause of non-syndromic sensorineural deafness autosomal recessive type 12 (DFNB12). Cadherin like 23 has also been associated with age-related hearing loss. -
细胞定位
Cell membrane; Single-pass type I membrane protein -
数据库链接
- Entrez Gene: 64072 Human
- Entrez Gene: 22295 Mouse
- Entrez Gene: 114102 Rat
- Omim: 605516 Human
- SwissProt: Q9H251 Human
- SwissProt: Q99PF4 Mouse
- SwissProt: P58365 Rat
-
别名
- Age related hearing loss 1 antibody
- Ahl 1 antibody
- Ahl antibody
see all
图片
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin like 23 antibody (ab131135)Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue labelling Cadherin like 23 with ab131135 at 1/100 dilution.
-
Immunocytochemistry/ Immunofluorescence - Anti-Cadherin like 23 antibody (ab131135)Immunofluorescence analysis of HeLa cells labelling Cadherin like 23 with ab131135 at 1/100 dilution. The picture on the right is treated with immunising peptide.
实验方案
数据表及文件
-
SDS download
-
Datasheet download
文献 (1)
ab131135 被引用在 1 文献中.
- Al-Choboq J et al. Usher Syndrome Belongs to the Genetic Diseases Associated with Radiosensitivity: Influence of the ATM Protein Kinase. Int J Mol Sci 23:N/A (2022). PubMed: 35163494