AB128910

重组Anti-CABP抗体[EPR7916]

Anti-CABP antibody [EPR7916]

RabMAb
Recombinant
了解详情

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(2 Publications)

Rabbit Recombinant Monoclonal CABP antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

查看别名

Calcium-binding protein 1, CaBP1, Calbrain, Caldendrin, CABP1

1 Images

Unknown

Western blot - Anti-CABP antibody [EPR7916] (AB128910)

All lanes:

Western blot - Anti-CABP antibody [EPR7916] (ab128910) at 1/1000 dilution

Lane 1:

Y79 cell lysate at 10 µg

Lane 2:

U-87 MG cell lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 40 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-CABP antibody [EPR7916] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR7916

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Conditional Ambient

储存信息

Stable for 12 months at -20°C

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CABP or Calcium-Binding Protein is a protein that modulates calcium signaling pathways. Alternate names include calbindin and calretinin though these may refer to specific types within the broader CABP family. CABP proteins vary in mass generally ranging from 10 to 50 kDa depending on the specific family member. These proteins are mainly expressed in the nervous system where they play an important role in regulating intracellular calcium levels. They also appear in other tissues like the heart and kidneys where they contribute to various cellular functions.

Biological function summary

The regulation of calcium ions by CABP influences several processes including neurotransmitter release muscle contraction and cell division. CABP proteins can be parts of larger complexes where they interact with other calcium-binding proteins to modulate calcium-dependent signaling mechanisms. Their function in the regulation of calcium homeostasis suggests a direct involvement in maintaining normal cellular functions especially in neurons.

Pathways

CABP proteins play integral roles in calcium signaling and related pathways. They are critical in modulating the response of cells to calcium transients by interacting with proteins such as calmodulin and calcineurin. CABP's role in these calcium-mediated pathways ensures proper synaptic activity and muscle response and is important for the plasticity of neuronal connections critical for learning and memory.

The dysfunction of CABP has links to neurodegenerative disorders and cardiac diseases. Alterations in CABP expression can contribute to conditions like Alzheimer's disease where calcium signaling becomes dysregulated. In addition aberrant CABP function may also play a role in cardiac hypertrophy due to imbalanced calcium handling often involving calmodulin and other calcium-dependent molecules. Understanding CABP's involvement in these conditions could provide insights into potential therapeutic strategies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs) (PubMed : 14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed : 15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed : 11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed : 15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed : 15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).

See full target information CABP1

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:1184 PubMed39885127

2025

Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction.

Applications

Unspecified application

Species

Unspecified reactive species

Thassio Mesquita,Rodrigo Miguel-Dos-Santos,Weixin Liu,Mario Fournier,Russell G Rogers,Jocelyn Alfaro,Asma Nawaz,Lizbeth Sanchez,Xaviar M Jones,Liang Li,Eduardo Marbán,Eugenio Cingolani

Biotechnology and applied biochemistry 72:104-115 PubMed39113388

2024

HPV18 E6/E7 activates Ca influx to promote the malignant progression of cervical cancer by inhibiting Ca binding protein 1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Cong Kang,Lei Qiu,Yali Duo,FengLing Bi,Zhongjie Liu,Jing Wang,Lei Zheng,Ning Zhao

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-CABP抗体[EPR7916]