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AB59140

Anti-C8 抗体 [056B-373]

Anti-C8 antibody [056B-373]

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(1 Publication)

Mouse Monoclonal CO8A antibody. Suitable for Flow Cyt, ELISA, WB, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human C8G.

查看别名

Complement component C8 alpha chain, Complement component 8 subunit alpha, C8A, Complement component C8 beta chain, Complement component 8 subunit beta, C8B, Complement component C8 gamma chain, C8G

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

056B-373

亚型

IgG1

不含载体蛋白

No

反应种属

Human

应用

Flow Cyt, IHC-Fr, ELISA, WB

applications

免疫原

Native Full Length Protein corresponding to Human C8G.

P07360

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搭配使用产品

Assay Kits

AB137971

Human Complement C8 ELISA Kit

Sandwich ELISA - Human Complement C8 ELISA Kit (AB137971)

  • 0
  • 0
Primary Antibodies

AB168345

Anti-C9 antibody [EPR11232]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C9 antibody [EPR11232] (AB168345)

  • 0
  • 0
Primary Antibodies

AB278045

Anti-Complement factor 8 beta/C8B antibody [EPR23764-1]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Complement factor 8 beta/C8B antibody [EPR23764-1] (AB278045)

  • 0
  • 0
Primary Antibodies

AB200999

Anti-C3 antibody [EPR19394]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Western blot - Anti-C3 antibody [EPR19394] (AB200999)

  • 4
  • 9
Primary Antibodies

AB133684

Anti-CD55 antibody [EPR6689]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD55 antibody [EPR6689] (AB133684)

  • 5
  • 1
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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产品详情

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
Preservative: 0.1% Sodium azide Constituents: 99% Borate buffered saline
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

C8 also known as complement component C8 is a protein that plays an important role in the immune system's complement pathway. This protein has a mass of approximately 151 kDa and is expressed mainly in the liver. It circulates in the blood plasma until activated. C8 is an integral part of the membrane attack complex (MAC) which forms pores in the cell membranes of pathogens leading to their destruction. The protein occurs as a heterotrimer composed of three subunits: alpha (C8A) beta (C8B) and gamma (C8G) each contributing to its function.
Biological function summary

Complement component C8 participates in the terminal phase of the complement cascade. Within this process it integrates into the MAC a large protein complex that forms on the surface of pathogens. The formation of MAC creates transmembrane channels that lead to cell lysis. C8 is part of a larger group of proteins known as the complement system which works to clear pathogens from an organism. Its assembly and function are dependent on previous steps in the complement activation pathway particularly interaction with components like C9 for forming the complete MAC.

Pathways

The complement component C8 is actively involved in the complement activation classical pathway and the alternative pathway. These pathways are important for the immune response aiding in the opsonization of pathogens and promoting inflammation. In the context of these pathways C8 interacts with other complement proteins such as C5b which is necessary for the initiation of MAC assembly. This interaction ensures the proper functioning of the complement responses safeguarding against infections.

Mutations or deficiencies in complement component C8 can lead to immunological abnormalities such as recurrent bacterial infections notably Neisseria infections. Individuals with C8 deficiency may suffer from increased susceptibility to such infections due to impaired MAC formation. Furthermore an inappropriate activation or regulation of complement pathways involving C8 can contribute to autoimmune diseases like systemic lupus erythematosus where other complement proteins like C3 also play an important role. Understanding the functioning of C8 in these contexts is essential for developing therapeutic interventions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.
See full target information C8A

其他靶点

C8G,C8B
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Food & nutrition research 61:1290740 PubMed28326005

2017

Bioactivity of food peptides: biological response of rats to bovine milk whey peptides following acute exercise.

Applications

Unspecified application

Species

Unspecified reactive species

Carolina Soares Moura,Pablo Christiano Barboza Lollo,Priscila Neder Morato,Eder Muller Risso,Jaime Amaya-Farfan
View all publications
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Abcam Product Promise

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详情请参阅我们的条款与条件。

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