Anti-C5抗体[11F6] (ab17930)
Key features and details
- Mouse monoclonal [11F6] to C5
- Suitable for: ELISA, WB
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-C5抗体[11F6]
参阅全部 C5 一抗 -
描述
小鼠单克隆抗体[11F6] to C5 -
宿主
Mouse -
特异性
ab17930 reacts with C5 in normal human plasma (PEG precipitated C5) in non reduced form only. No reaction is seen with plasma from C5 deficient patients. -
经测试应用
适用于: ELISA, WBmore details -
种属反应性
与反应: Human -
免疫原
Full length native C5 protein, isolated from human plasma.
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表位
Epitope specificity differs from that of ab17457 but slightly overlaps as determined by inhibition ELISA. -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
11F6 -
骨髓瘤
x63-Ag8.653 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab17930于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ELISA | (1) |
Use at an assay dependent concentration.
|
WB |
Use at an assay dependent concentration. Predicted molecular weight: 188 kDa.
Recognises C5 in non-reduced form only. |
说明 |
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ELISA
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. Predicted molecular weight: 188 kDa. Recognises C5 in non-reduced form only. |
靶标
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功能
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). -
疾病相关
Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:609536]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705). -
序列相似性
Contains 1 anaphylatoxin-like domain.
Contains 1 NTR domain. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 727 Human
- Omim: 120900 Human
- SwissProt: P01031 Human
- Unigene: 494997 Human
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别名
- Anaphylatoxin C5a analog antibody
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody
- C5 antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab17930 尚未被引用在任何文献中。