AB126250

Anti-C3a R 抗体

Name: C3a R抗体 (ab126250)| Abcam中文官网
Brand: Abcam Limited
SKU: AB126250
Price: 4829 CNY
Availability: InStock

Anti-C3a R antibody

Be the first to review this product! Submit a review

(10 Publications)

Rabbit Polyclonal C3a R antibody. Suitable for WB and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Recombinant Fragment Protein within Human C3AR1 aa 1-250.

查看别名

AZ3B, C3R1, HNFAG09, C3AR1, C3a anaphylatoxin chemotactic receptor, C3AR, C3a-R

2 Images

Supplier Data

Western blot - Anti-C3a R antibody (AB126250)

Samples were separated by 10% SDS-PAGE.

All lanes:

Western blot - Anti-C3a R antibody (ab126250) at 1/500 dilution

Lane 1:

HL-60 whole cell extracts at 30 µg

Lane 2:

HL-60 membrane extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 54 kDa

false

Supplier Data

Western blot - Anti-C3a R antibody (AB126250)

Samples were separated by 10% SDS-PAGE.

All lanes:

Western blot - Anti-C3a R antibody (ab126250) at 1/500 dilution

Lane 1:

Unboiled HL-60 whole cell extracts at 30 µg

Lane 2:

Unboiled C3a Receptor shRNA transfected HL-60 whole cell lysates at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 54 kDa

true

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Fragment Protein within Human C3AR1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q16581

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p>Optimal working dilutions should be determined experimentally by the user</p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Macaque monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Primates": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The C3a receptor also known as C3aR or C3aR1 is a critical component of the immune system. It functions by binding to the C3a peptide a product of the complement cascade. This binding triggers a variety of immune responses. C3aR is a surface receptor widely expressed on immune cells such as macrophages mast cells and neutrophils. The molecular weight of the C3a receptor is approximately 55 kDa. It can be found principally in tissues involved in immunity like the spleen lungs and liver.

Biological function summary

The C3a receptor plays an important role in the immune response by mediating inflammatory reactions. It is not part of a larger complex like some receptors functioning instead through protein-protein interactions. Upon activation by binding with the C3a peptide the receptor can promote the release of histamine cytokines and other inflammatory mediators. This action helps regulate the body's defense against pathogens and contributes to the elimination of foreign materials from the body.

Pathways

The C3a receptor is involved in the complement pathway and immune response pathways. It interacts with several proteins within these pathways including C3a protein itself and other complement components. By engaging in these pathways C3aR significantly influences cellular responses and activities. For example its activation can lead to the alteration of immune cell behavior enhancing phagocytosis and increasing cell migration to sites of infection or injury.

The C3a receptor has been implicated in asthma and rheumatoid arthritis. In asthma C3aR activation can lead to overactive immune responses causing increased bronchoconstriction and airway hyperresponsiveness. Its involvement in rheumatoid arthritis relates to its ability to modulate inflammation exacerbating joint damage and discomfort. The receptor's activity in these conditions can also connect it to other proteins such as specific inflammatory cytokines which contribute to the pathological processes seen in these diseases.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, stimulating chemotaxis, granule enzyme release and superoxide anion production (PubMed : 12871936, PubMed : 37852260, PubMed : 8702752). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 37852260). C3AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed : 37852260).

See full target information C3AR1

style

left-column

文献 (10)

Recent publications for all applications. Explore the full list and refine your search

PloS one 20:e0331900 PubMed40939011

2025

C3AR1 may aggravate diabetic nephropathy by mediating oxidative stress via ITGB2 regulation in renal tubular epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Alex Abura,Shan Gao

International journal of molecular sciences 26: PubMed39940693

2025

Establishment of a Panel of Human Cell Lines to Identify Cellular Receptors Used by to Infect Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Anastasiia O Sosnovtseva,Thi Hoa Le,Dmitry S Karpov,Pavel O Vorobyev,Yana D Gumennaya,Olga N Alekseeva,Peter M Chumakov,Anastasia V Lipatova

Neuron 111:3619-3633.e8 PubMed37689059

2023

Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Eunhee Kim,Hyeonwoo Kim,Mark P Jedrychowski,Grisilda Bakiasi,Joseph Park,Jane Kruskop,Younjung Choi,Sang Su Kwak,Luisa Quinti,Doo Yeon Kim,Christiane D Wrann,Bruce M Spiegelman,Rudolph E Tanzi,Se Hoon Choi

Experimental and therapeutic medicine 24:493 PubMed35837068

2022

The complement C3a-C3aR and C5a-C5aR pathways promote viability and inflammation of human retinal pigment epithelium cells by targeting NF-κB signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Shasha Luo,Huiyan Xu,Xuechun Gong,Jinyan Shen,Xuan Chen,Zhifeng Wu

International journal of molecular sciences 22: PubMed34299197

2021

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

Applications

Unspecified application

Species

Unspecified reactive species

Fernanda Mansur,André Luiz Teles E Silva,Ana Karolyne Santos Gomes,Juliana Magdalon,Janaina Sena de Souza,Karina Griesi-Oliveira,Maria Rita Passos-Bueno,Andréa Laurato Sertié

International journal of molecular sciences 22: PubMed34066088

2021

Alternative C3 Complement System: Lipids and Atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Maisa Garcia-Arguinzonis,Elisa Diaz-Riera,Esther Peña,Rafael Escate,Oriol Juan-Babot,Pedro Mata,Lina Badimon,Teresa Padro

Frontiers in medicine 8:642615 PubMed33748161

2021

C3AR1 mRNA as a Potential Therapeutic Target Associates With Clinical Outcomes and Tumor Microenvironment in Osteosarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Tiannan Zou,Weibing Liu,Zeyu Wang,Jiayu Chen,Sheng Lu,Kun Huang,Weichao Li

Cancer cell international 20:223 PubMed32528231

2020

Circular RNA circUBAP2 regulates proliferation and invasion of osteosarcoma cells through miR-641/YAP1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Haojie Wu,Weihua Li,Shutao Zhu,Dengfeng Zhang,Minghui Zhang

Brain research 1698:81-88 PubMed29909203

2018

Neuronal complement cascade drives bone cancer pain via C3R mediated microglial activation.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxia Huang,Jinyuan Li,Jin Xie,Yang Li,Yan Gao,Xiaohui Li,Xueqin Xu,Ruoshi Shi,Wanjun Yao,Changbin Ke

Experimental and therapeutic medicine 14:2493-2496 PubMed28962185

2017

Evaluation of expression levels and mechanism of complement activation.

Applications

Unspecified application

Species

Unspecified reactive species

Xing Wang,An-Heng Liu,Zhong-Wei Jia,Kui Pu,Kang-Yin Chen,Hua Guo

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-C3a R 抗体

Anti-C3a R antibody

Western blot - Anti-C3a R antibody (AB126250)

Western blot - Anti-C3a R antibody (AB126250)