AB103629

Anti-C3a R抗体

Name: C3a R抗体 (ab103629)| Abcam中文官网
Brand: Abcam Limited
SKU: AB103629
Price: 4973 CNY
Availability: InStock

Anti-C3a R antibody

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(1 Publication)

Rabbit Polyclonal C3a R antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human C3AR1.

查看别名

AZ3B, C3R1, HNFAG09, C3AR1, C3a anaphylatoxin chemotactic receptor, C3AR, C3a-R

2 Images

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Western blot - Anti-C3a R antibody (AB103629)

All lanes:

Western blot - Anti-C3a R antibody (ab103629) at 5 µg/mL

Lane 1:

C3a R transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Predicted band size: 53 kDa

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Western blot - Anti-C3a R antibody (AB103629)

All lanes:

Western blot - Anti-C3a R antibody (ab103629) at 5 µg/mL

All lanes:

Human liver tissue lysate at 50 µg

Predicted band size: 53 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Full Length Protein corresponding to Human C3AR1.

Q16581

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The C3a receptor also known as C3aR or C3aR1 is a critical component of the immune system. It functions by binding to the C3a peptide a product of the complement cascade. This binding triggers a variety of immune responses. C3aR is a surface receptor widely expressed on immune cells such as macrophages mast cells and neutrophils. The molecular weight of the C3a receptor is approximately 55 kDa. It can be found principally in tissues involved in immunity like the spleen lungs and liver.

Biological function summary

The C3a receptor plays an important role in the immune response by mediating inflammatory reactions. It is not part of a larger complex like some receptors functioning instead through protein-protein interactions. Upon activation by binding with the C3a peptide the receptor can promote the release of histamine cytokines and other inflammatory mediators. This action helps regulate the body's defense against pathogens and contributes to the elimination of foreign materials from the body.

Pathways

The C3a receptor is involved in the complement pathway and immune response pathways. It interacts with several proteins within these pathways including C3a protein itself and other complement components. By engaging in these pathways C3aR significantly influences cellular responses and activities. For example its activation can lead to the alteration of immune cell behavior enhancing phagocytosis and increasing cell migration to sites of infection or injury.

The C3a receptor has been implicated in asthma and rheumatoid arthritis. In asthma C3aR activation can lead to overactive immune responses causing increased bronchoconstriction and airway hyperresponsiveness. Its involvement in rheumatoid arthritis relates to its ability to modulate inflammation exacerbating joint damage and discomfort. The receptor's activity in these conditions can also connect it to other proteins such as specific inflammatory cytokines which contribute to the pathological processes seen in these diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, stimulating chemotaxis, granule enzyme release and superoxide anion production (PubMed : 12871936, PubMed : 37852260, PubMed : 8702752). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 37852260). C3AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed : 37852260).

See full target information C3AR1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 9:6801 PubMed31043634

2019

Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure.

Applications

Unspecified application

Species

Unspecified reactive species

Michael Lawless,Jessica L Caldwell,Emma J Radcliffe,Charlotte E R Smith,George W P Madders,David C Hutchings,Lori S Woods,Stephanie J Church,Richard D Unwin,Graeme J Kirkwood,Lorenz K Becker,Charles M Pearman,Rebecca F Taylor,David A Eisner,Katharine M Dibb,Andrew W Trafford

View all publications

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Anti-C3a R抗体

Anti-C3a R antibody

Western blot - Anti-C3a R antibody (AB103629)

Western blot - Anti-C3a R antibody (AB103629)