Anti-C1q抗体[JL-1] (ab71940)
![ELISA - Anti-C1q antibody [JL-1] (ab71940)](https://www.abcam.cn/ps/products/71/ab71940/Images/ab71940-415217-anti-c1q-antibody-elisa.jpg "ELISA - Anti-C1q antibody [JL-1] (ab71940)")
Key features and details
- Mouse monoclonal [JL-1] to C1q
- Suitable for: Dot blot, ELISA
- Reacts with: Mouse, Human
- Isotype: IgG2b
概述
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产品名称
Anti-C1q抗体[JL-1]
参阅全部 C1q 一抗 -
描述
小鼠单克隆抗体[JL-1] to C1q -
宿主
Mouse -
经测试应用
适用于: Dot blot, ELISAmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat
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免疫原
Purified mouse C1q
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表位
The monoclonal antibody JL-1is reactive with the collagen-like region (CLR). -
常规说明
The antibody has been generated by immunization of C1q-/- C57BL/6 mice with purified mouse C1q.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Constituents: 0.1% BSA, PBS -
Concentration information loading... -
纯度
Protein G purified -
纯化说明
0.2µm filtered. -
克隆
单克隆 -
克隆编号
JL-1 -
同种型
IgG2b -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab71940于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Dot blot |
Use at an assay dependent concentration.
|
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| ELISA | (1) |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
Dot blot
Use at an assay dependent concentration. |
|
ELISA
Use at an assay dependent concentration. |
靶标
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功能
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. -
疾病相关
Defects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. -
序列相似性
Contains 1 C1q domain.
Contains 1 collagen-like domain. -
翻译后修饰
O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 712 Human
- Entrez Gene: 713 Human
- Entrez Gene: 714 Human
- Entrez Gene: 12259 Mouse
- Entrez Gene: 12260 Mouse
- Entrez Gene: 12262 Mouse
- Entrez Gene: 29687 Rat
- Entrez Gene: 298566 Rat
see all -
别名
- C1qa antibody
- C1QA_HUMAN antibody
- C1QB antibody
see all
图片
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ELISA - Anti-C1q antibody [JL-1] (ab71940)
ab71940 was used as a detection antibody in different concentrations.
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![Dot Blot - Anti-C1q antibody [JL-1] (ab71940)](https://www.abcam.cn/ps/products/71/ab71940/Images/ab71940-415216-anti-c1q-antibody-dot-blot.jpg)
Dot Blot - Anti-C1q antibody [JL-1] (ab71940)Dot blot with ab71940 with mouse serum and human plasma with different amounts of C1q.
数据表及文件
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Datasheet download
文献 (38)
ab71940 被引用在 38 文献中.
- Grover A et al. Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates. Invest Ophthalmol Vis Sci 64:3 (2023). PubMed: 36729444
- Zhou Y et al. Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys. J Neuroinflammation 20:201 (2023). PubMed: 37660145
- Bao L et al. Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution. Bioact Mater 9:183-197 (2022). PubMed: 34820565
- Miller-Rhodes P et al. URMC-099 prophylaxis prevents hippocampal vascular vulnerability and synaptic damage in an orthopedic model of delirium superimposed on dementia. FASEB J 36:e22343 (2022). PubMed: 35535564
- De Gaetano GV et al. Streptococcus pneumoniae binds collagens and C1q via the SSURE repeats of the PfbB adhesin. Mol Microbiol 117:1479-1492 (2022). PubMed: 35570359
