Anti-Butyrylcholinesterase抗体[3E8] (ab17246)
![ELISA - Anti-Butyrylcholinesterase antibody [3E8] (ab17246)](https://www.abcam.cn/ps/products/17/ab17246/Images/ab17246-283478-anti-butyrylcholinesterase-antibody-3e8-elisa.jpg "ELISA - Anti-Butyrylcholinesterase antibody [3E8] (ab17246)")
Key features and details
- Mouse monoclonal [3E8] to Butyrylcholinesterase
- Suitable for: ELISA
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-Butyrylcholinesterase抗体[3E8]
参阅全部 Butyrylcholinesterase 一抗 -
描述
小鼠单克隆抗体[3E8] to Butyrylcholinesterase -
宿主
Mouse -
特异性
No reaction is seen with acetylcholinesterase from human nervous tissue and erythrocytes. -
经测试应用
适用于: ELISAmore details
不适用于: WB -
种属反应性
与反应: Human -
免疫原
Full length native protein (purified) corresponding to Human Butyrylcholinesterase. (Isolated from human plasma).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. Store In the Dark. -
存储溶液
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading... -
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
3E8 -
骨髓瘤
x63-Ag8.653 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab17246于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
1/8000.
|
| 说明 |
|---|
|
ELISA
1/8000. |
靶标
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功能
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. -
组织特异性
Detected in blood plasma (at protein level). Present in most cells except erythrocytes. -
疾病相关
Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. -
序列相似性
Belongs to the type-B carboxylesterase/lipase family. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 590 Human
- Omim: 177400 Human
- SwissProt: P06276 Human
- Unigene: 420483 Human
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别名
- Acylcholine acylhydrolase antibody
- BCHE antibody
- Butyrylcholine esterase antibody
see all
图片
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ELISA - Anti-Butyrylcholinesterase antibody [3E8] (ab17246)
Calibration curve of a sandwich assay for Butyrylcholinesterase using ab17246 as the capture antibody and a biotinylated detection antibody.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab17246 被引用在 3 文献中.
- Li J et al. Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase. Nat Commun 12:896 (2021). PubMed: 33563994
- Sinclair LI et al. Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas. Alzheimers Res Ther 11:80 (2019). PubMed: 31511061
- Yang M et al. Simultaneous detection of dual biomarkers from humans exposed to organophosphorus pesticides by combination of immunochromatographic test strip and ellman assay. Biosens Bioelectron 104:39-44 (2018). PubMed: 29306031