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AB17246

Anti-Butyrylcholinesterase 抗体 [3E8]

Anti-Butyrylcholinesterase antibody [3E8]

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(3 Publications)

Mouse Monoclonal Butyrylcholinesterase antibody. Suitable for ELISA and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human BCHE.

查看别名

CHE1, BCHE, Cholinesterase, Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase

1 Images
ELISA - Anti-Butyrylcholinesterase antibody [3E8] (AB17246)
  • ELISA

Supplier Data

ELISA - Anti-Butyrylcholinesterase antibody [3E8] (AB17246)

Calibration curve of a sandwich assay for Butyrylcholinesterase using ab17246 as the capture antibody and a biotinylated detection antibody.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

3E8

亚型

IgG1

轻链类型

kappa

不含载体蛋白

No

反应种属

Human

应用

ELISA

applications

免疫原

Native Full Length Protein corresponding to Human BCHE.

P06276

特异性

No reaction is seen with acetylcholinesterase from human nervous tissue and erythrocytes.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "testedAndGuaranteed", "ELISA-species-dilution-info": "1/8000", "ELISA-species-notes": "<p></p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
存储溶液
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 2.9% Sodium chloride
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
储存信息
Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Butyrylcholinesterase often called BuChE or BChE is a serine hydrolase enzyme that catalyzes the hydrolysis of ester compounds such as butyrylcholine. It has a molecular mass of approximately 85 kDa. BChE is structurally similar to acetylcholinesterase (AChE) and is found in various tissues with high expression in the liver plasma and the central nervous system. This enzyme acts as a scavenger by breaking down circulating choline esters and certain therapeutic drugs playing an important role in detoxifying the blood.
Biological function summary

This enzyme is significant in nervous system function and is not restricted to acetylcholine breakdown but can hydrolyze larger ester molecules. It forms part of a complex regulatory mechanism alongside acetylcholinesterase ensuring precise modulating of neurotransmitter signaling. BChE can also serve as a backup to acetylcholinesterase in breaking down neurotransmitters therefore contributing to maintaining synaptic balance and functionality.

Pathways

BuChE is involved in the cholinergic signaling pathway playing a significant role in neurotransmitter regulation. This pathway is important for muscle activation and memory processing. BChE also impacts the metabolism of certain ester-type drugs used in anesthesia. Its activity balances with acetylcholinesterase modulating the availability of acetylcholine within synaptic clefts and seamlessly integrating into broader physiological processes.

Altered BChE activity correlates with Alzheimer's disease and certain liver diseases. In Alzheimer's decreased BChE activity parallels reduced acetylcholinesterase function which affects cholinergic transmission in the brain contributing to memory deficits. Disorders like liver cirrhosis also show a compromised BChE level due to liver's impaired enzyme production aligning it closely with liver function and disease diagnostics.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
See full target information BCHE
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 12:896 PubMed33563994

2021

Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Li,Barun Mahata,Mario Escobar,Jacob Goell,Kaiyuan Wang,Pranav Khemka,Isaac B Hilton

Alzheimer's research & therapy 11:80 PubMed31511061

2019

Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas.

Applications

Unspecified application

Species

Unspecified reactive species

Lindsey Isla Sinclair,Amit Kumar,Taher Darreh-Shori,Seth Love

Biosensors & bioelectronics 104:39-44 PubMed29306031

2018

Simultaneous detection of dual biomarkers from humans exposed to organophosphorus pesticides by combination of immunochromatographic test strip and ellman assay.

Applications

Unspecified application

Species

Unspecified reactive species

Mingming Yang,Yuting Zhao,Limin Wang,Michael Paulsen,Christopher D Simpson,Fengquan Liu,Dan Du,Yuehe Lin
View all publications
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替代产品

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Primary Antibodies

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Primary Antibodies

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搭配使用产品

Assay Kits

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Primary Antibodies

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Primary Antibodies

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Secondary Antibodies

AB150077

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Primary Antibodies

AB126751

Anti-Monoamine Oxidase A/MAO-A antibody [EPR7101]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Monoamine Oxidase A/MAO-A antibody [EPR7101] (AB126751)

  • 5
  • 4

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