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Anti-BOTOX抗体[230F9] (ab40786)

Submit a review Q&A (1)References (1)

Key features and details

  • Mouse monoclonal [230F9] to BOTOX
  • Suitable for: ICC/IF, Inhibition Assay
  • Reacts with: Species independent
  • Isotype: IgG

概述

  • 产品名称

    Anti-BOTOX抗体[230F9]
    参阅全部 BOTOX 一抗

  • 描述

    小鼠单克隆抗体[230F9] to BOTOX

  • 宿主

    Mouse

  • 特异性

    BoTox-A (1280-1292) 100%; BoTox-A 100% Does not cross react with BoTox-B, BoTox-C, BoTox-E or BoTox-F (1272-1280)

  • 经测试应用

    适用于: ICC/IF, Inhibition Assaymore details

  • 种属反应性

    与反应: Species independent

  • 免疫原

    Synthetic peptide corresponding to BOTOX (C terminal).

  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

  • 形式

    Liquid

  • 存放说明

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

  • 存储溶液

    Constituent: Tissue culture supernatant
  • Concentration information loading...

  • 纯度

    Tissue culture supernatant

  • 纯化说明

    Sterile filtered culture supernatant.

  • 克隆

    单克隆

  • 克隆编号

    230F9

  • 同种型

    IgG

  • 研究领域

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab40786于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
ICC/IF
Use at an assay dependent concentration.
Inhibition Assay
Use at an assay dependent concentration.

Inhibits BoTox-A binding to Neuro2A cells treated with GT1b ganglioside which can be eliminated by prior incubation with synthetic peptide immunogen.
说明
ICC/IF
Use at an assay dependent concentration.
Inhibition Assay
Use at an assay dependent concentration.

Inhibits BoTox-A binding to Neuro2A cells treated with GT1b ganglioside which can be eliminated by prior incubation with synthetic peptide immunogen.

靶标

  • 相关性

    Clostridium botulinum neurotoxins are zinc-dependent proteases that block the release of acetylcholine from peripheral cholinergic nerve endings by targeting specific membrane proteins including synaptosomal-associated proteins (SNAP), vesicle-associated membrane proteins (VAMP), and syntaxins. Neurotoxin A is characteristically associated with human botulism and known to target and hydrolyse the 197-Gln-|-Arg-198 bond of SNAP-25.

  • 别名

    • Atx antibody
    • BotA antibody
    • BOTOX antibody
    • Botulinum neurotoxin type A antibody
    • Botulism A toxoid antibody
    • Clostridium botulinum A Toxoid antibody
    see all

文献 (1)

发表研究结果有使用 ab40786？请让我们知道，以便我们可以引用本数据表中的参考文章。

ab40786 被引用在 1 文献中.

  • Bräuer L  et al. Staphylococcus aureus and Pseudomonas aeruginosa express and secrete human surfactant proteins. PLoS One 8:e53705 (2013). PubMed: 23349731

客户评价及客户问答

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Question

this is to have some clarification about the product Anti-Clostridium botulinum A Toxoid antibody [230F9] (ab40786).
Does it reacts well with the whole toxin? We need for an antibody that can recognize the Botulinum toxin inside the cells to look whether cells can internalize the toxin. Moreover it is tested for IF/ICC: do you think it could work also in western blot?

Thanks for your assistance

Best regards,

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Answer

Thank you for contacting us.

The immunogen of antibody ab40786 is a "synthetic peptide analogue of the carboxyl terminal region of BoTox-A", http://www.uniprot.org/uniprot/P10845.

We have not tested this antibody in WB, if you are interested in testing this ba in WB then you might be interested in our Abtrial offer. Please click the link below for more information.

https://www.abcam.com/index.html?pageconfig=resource&rid=11998&viapagetrap=collaborationdiscount

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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