AB182149

重组Anti-Bora抗体[EPR11610]

Anti-Bora antibody [EPR11610]

RabMAb
Recombinant
了解详情

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(2 Publications)

Rabbit Recombinant Monoclonal BORA antibody. Suitable for IP, WB, ICC/IF and reacts with Human samples. Cited in 2 publications.

查看别名

C13orf34, BORA, Protein aurora borealis, HsBora

4 Images

Immunocytochemistry/ Immunofluorescence - Anti-Bora antibody [EPR11610] (AB182149)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Bora antibody [EPR11610] (AB182149)

Immunofluorescent analysis of HeLa cells (-20°C Acetone-fixed) labeling Bora with ab182149 at 1/250 dilution followed by Goat anti rabbit IgG (Alexa Fluor® 488) secondary at 1/200 diution.

Supplier Data

Immunoprecipitation - Anti-Bora antibody [EPR11610] (AB182149)

Western blot analysis of immunoprecipitation pellet from HeLa cell lysate immunoprecipitated using ab182149 at 1/40 dilution.

Secondary : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution.

All lanes:

Immunoprecipitation - Anti-Bora antibody [EPR11610] (ab182149)

Predicted band size: 61 kDa

false

Supplier Data

Western blot - Anti-Bora antibody [EPR11610] (AB182149)

All lanes:

Western blot - Anti-Bora antibody [EPR11610] (ab182149) at 1/10000 dilution

All lanes:

Jurkat cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 61 kDa

false

Supplier Data

Western blot - Anti-Bora antibody [EPR11610] (AB182149)

All lanes:

Western blot - Anti-Bora antibody [EPR11610] (ab182149) at 1/10000 dilution

Lane 1:

Human fetal brain tissue lysate at 20 µg

Lane 2:

HeLa cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 61 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-Bora antibody [EPR11610] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR11610

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, IP, ICC/IF

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/40", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/250", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯度

Tissue culture supernatant

存储溶液

pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Bora protein also known by its aliases Bora Rabbit or Bora Compliance plays a significant role in cell cycle regulation. It is a cofactor that primarily interacts with Aurora A kinase to promote activation. Bora protein weighs around 58 kilodaltons and is notably expressed in various tissues including those involved in cell division activities such as the reproductive organs and the skin.

Biological function summary

Bora protein's primary role involves cell cycle progression and the maintenance of genomic integrity. It forms part of a regulatory complex that ensures proper mitotic entry linking it closely with mitotic spindle formation and centrosome maturation processes. The Bora protein is pivotal in activating Aurora A kinase therefore ensuring accurate chromosome segregation during mitosis.

Pathways

The Bora protein is deeply integrated into cell cycle regulation and mitotic spindle checkpoint pathways. It functions as an upstream regulator within the Aurora A kinase pathway impacting downstream processes that involve key proteins such as Plk1 and Cdc25B. Through these interactions Bora protein helps monitor and coordinate entry into mitosis highlighting its centrality in mitotic timing and fidelity.

Abnormal expression or mutations in the Bora protein can lead to tumorigenesis and cancer progression. Specifically it is associated with disorders such as breast cancer and ovarian cancer. The dysregulation of Bora's interaction with Aurora A kinase and other proteins like p53 can contribute to aberrant cell cycle progression highlighting its involvement in the pathogenesis of cancer.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Required for the activation of AURKA at the onset of mitosis.

See full target information BORA

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cells 14: PubMed39791720

2025

Induction of SUSD2 by STAT3 Activation Is Associated with Tumor Recurrence in HER2-Positive Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yisun Jeong,Hyungjoo Kim,Daeun You,Soo Youn Cho,Sun Young Yoon,Seok Won Kim,Seok Jin Nam,Jeong Eon Lee,Sangmin Kim

Journal of hematology & oncology 12:67 PubMed31253167

2019

Potential immune escape mechanisms underlying the distinct clinical outcome of immune checkpoint blockades in small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yaru Tian,Xiaoyang Zhai,Anqin Han,Hui Zhu,Jinming Yu

View all publications

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重组Anti-Bora抗体[EPR11610]