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Anti-BMPR2抗体(ab106266)

Submit a review Q&A (1)References (4)
Western blot - Anti-BMPR2 antibody (ab106266)

    Key features and details

    • Rabbit polyclonal to BMPR2
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    概述

    • 产品名称

      Anti-BMPR2抗体
      参阅全部 BMPR2 一抗

    • 描述

      兔多克隆抗体to BMPR2

    • 宿主

      Rabbit

    • 经测试应用

      适用于: WBmore details

    • 种属反应性

      与反应: Human
      预测可用于: Mouse, Rat

    • 免疫原

      Recombinate fragment, corresponding to amino acids 295 - 552 of Human BMPR2 (BC052985).

    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab106266于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    WB
    1/500 - 1/1000. Predicted molecular weight: 115 kDa.
    说明
    WB
    1/500 - 1/1000. Predicted molecular weight: 115 kDa.

    靶标

    • 功能

      On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

    • 组织特异性

      Highly expressed in heart and liver.

    • 疾病相关

      Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1) [MIM:178600]. PPH1 is a rare autosomal dominant disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
      Defects in BMPR2 are a cause of pulmonary venoocclusive disease (PVOD) [MIM:265450]. PVOD is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with PPH1 has been speculative. The finding of PVOD associated with a BMPR2 mutation reveals a possible pathogenetic connection with PPH1.

    • 序列相似性

      Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
      Contains 1 protein kinase domain.

    • 细胞定位

      Membrane.
    • Information by UniProt

    • 数据库链接

      see all

    • 别名

      • BMP type II receptor antibody
      • BMP type-2 receptor antibody
      • BMPR 2 antibody
      • BMPR 3 antibody
      • BMPR II antibody
      • BMPR-2 antibody
      • BMPR-II antibody
      • Bmpr2 antibody
      • BMPR2_HUMAN antibody
      • BMPR3 antibody
      • BMPRII antibody
      • BMR 2 antibody
      • BMR2 antibody
      • Bone morphogenetic protein receptor type 2 antibody
      • Bone morphogenetic protein receptor type II antibody
      • Bone morphogenetic protein receptor type-2 antibody
      • Bone morphogenic protein receptor type II serine threonine kinase antibody
      • BRK 3 antibody
      • BRK3 antibody
      • PPH 1 antibody
      • PPH1 antibody
      • Serine threonine kinase type II activin receptor like kinase antibody
      • T ALK antibody
      • TALK antibody
      • Type II activin receptor like kinase antibody
      see all

    图片

    • Western blot - Anti-BMPR2 antibody (ab106266)
      Western blot - Anti-BMPR2 antibody (ab106266)
      Anti-BMPR2 antibody (ab106266) at 1/500 dilution + Raji cell lysate

      Predicted band size: 115 kDa

    文献 (4)

    发表研究结果有使用 ab106266？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab106266 被引用在 4 文献中.

    • Ma B  et al. Gremlin is a potential target for posterior capsular opacification. Cell Cycle 18:1714-1726 (2019). PubMed: 31234714
    • Xu X  et al. Endocardial fibroelastosis is caused by aberrant endothelial to mesenchymal transition. Circ Res 116:857-66 (2015). PubMed: 25587097
    • Gao X  et al. Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis. PLoS One 9:e89114 (2014). Mouse . PubMed: 24586530
    • Zhu YT  et al. Activation of RhoA-ROCK-BMP signaling reprograms adult human corneal endothelial cells. J Cell Biol 206:799-811 (2014). Human . PubMed: 25202030

    客户评价及客户问答

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    Question

    To whom it may concern,   I’m interested in your products with the references ab6285 and ab78422. I would like to know if you have any information on the cross reactivity of the products with zebrafish samples. If not, would it be possible for you to send me a sample so I can try the antibodies on my samples?   Thank you very much for the attention,   Sincerely,      

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    Answer

    Thank you for your enquiry which has been forwarded to the scientific support team. I am sorry to confirm that because we carry over 70,000 products, it is not feasible for us to keep small sample sizes of our products to send to cusotmers. We are happy to reassure our customers that all of our products are covered by our Abpromise, which guarantees that the product will work in the applications and species specified on the datasheet, or we will offer a replacement, credit, or refund within 6 months of purchase. With regards to ab6285 Anti-BMP2 antibody [65529.111], I have reviewed the alingment of the immunogen for this antibody to the Zebrafish protein. There is 63% alignment to zebrafish. This alignment is quite low and I would therefore not recommend that this antibody is likely to detect the Zebrafish BMP2. The other antibodies we have to BMP2 are raised against full length human protein or shorter peptides from the human sequence, and they all have the same alignment or less. I am sorry there are no BMP2 antibodies to suggest that may be suitable on this occasion. With regards to BMPR2, the immunogen of ab78422 BMPR2 has only 58% alignment to zebrafish. Again, I am sorry this means it is not likely to crossreact with Zebrafish. However, we do have the following BMPR2 antibody which has 88% alignment to the zebrafish protein. I can recommend to review the online datasheet for further details. BMPR2 antibody (ab106266) https://www.abcam.com/BMPR2-antibody-ab106266.html https://www.abcam.com/BMPR2-antibody-ab106266.html. If you would like to test this antibody in Zebrafish, you may be eligible for our testing discount program if the antibody has not yet been purchased. Please contact our Scientific Support team by replying to this email prior to purchase for more information. Otherwise, we like to encourage all of our customers to submit an Abreview via the online product datasheet. We always appreciate customer feedback, whether positive or negative, and we make all product information available to researchers. Plus, each Abreview earns Abpoints that can be used for discounts on future purchases or rewards such as Amazon.com gift certificates. To find out more about our Abreview system, please see the following link: https://www.abcam.com/abreviews I hope this information is helpful. Please do not hesitate to contact me again with any other questions.

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