AB219336

Anti-Blood Group Lewis y抗体[LWY/1463]

Name: Blood Group Lewis y抗体[LWY/1463] (ab219336)| Abcam中文官网
Brand: Abcam Limited
SKU: AB219336
Price: 4864 CNY
Availability: InStock

Anti-Blood Group Lewis y antibody [LWY/1463]

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(2 Publications)

Mouse Monoclonal Blood Group Lewis y antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing Blood Group Lewis y protein.

查看别名

Lewis Y blood group

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Blood Group Lewis y antibody [LWY/1463] (AB219336)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Blood Group Lewis y antibody [LWY/1463] (AB219336)

Immunohistochemical analysis of formalin fixed paraffin embedded Human lung carcinoma tissue labeling Blood Group Lewis y with ab219336 at 1 μg/mL.

Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

LWY/1463

亚型

IgG1

轻链类型

kappa

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A/G

存储溶液

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Blood Group Lewis y also known as Le^y or the Lewis y antigen is a carbohydrate antigen found on the surface of red blood cells and certain epithelial tissues. It is a fucosylated oligosaccharide structure specifically an f3-Lewis structure with a molecular mass around 725 Daltons. The Lewis y antigen is expressed most strongly in the epithelial cells of the gastrointestinal tract lungs and urinary tract. It also appears in the endothelial cells of blood vessels and some tumor cells where it can act as a tumor-associated carbohydrate antigen.

Biological function summary

The Lewis y antigen plays a significant role in cell adhesion and cell-cell recognition. It becomes engaged in the regulation of cellular interaction being part of complex glycoproteins and glycolipids on cell membranes. These structures serve as ligands for selectins which are adhesion molecules involved in immune responses. The presence of Lewis y antigen can influence cellular behavior and interactions impacting immune response and tumor progression.

Pathways

The Lewis y antigen is involved in the selectin-mediated signaling pathway and glycosylation processes. These pathways relate to its role in cell adhesion and immune system navigation where it interacts with selectin proteins such as L-selectin and E-selectin. Glycosyltransferases enzymes part of the glycosylation process modify the Lewis y antigen forming structures essential for proper cellular recognition and communication in various physiological contexts.

The Lewis y antigen has associations with certain types of cancer such as epithelial ovarian and gastric cancers. It often becomes overexpressed in tumor cells making it a marker for cancer progression and a target for cancer immunotherapy. The upregulation of the Lewis y antigen might interact with molecules like HER2/neu a protein commonly overexpressed in cancer cells contributing to aggressive tumor behavior and metastasis.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information Blood Group Lewis y

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 23:136 PubMed40082910

2025

Basal cell adhesion molecule (BCAM) promotes mesothelial-to-mesenchymal transition and tumor angiogenesis through paracrine signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Suresh Sivakumar,Sonja Lieber,Raimund Dietze,Vanessa M Beutgen,Eileen C Sutor,Sophie Heidemann,Florian Finkernagel,Julia Teply-Szymanski,Andrea Nist,Thorsten Stiewe,Katrin Roth,Silke Reinartz,Johannes Graumann,Sabine Müller-Brüsselbach,Rolf Müller

International journal of molecular sciences 24: PubMed37958597

2023

Features and Comparative Characteristics of Fucosylated Glycans Expression in Endothelial Glycocalyx of Placental Terminal Villi in Patients with Preeclampsia Treated with Different Antihypertensive Regimens.

Applications

Unspecified application

Species

Unspecified reactive species

Marina M Ziganshina,Galina V Kulikova,Kamilla T Muminova,Alexander I Shchegolev,Ekaterina L Yarotskaya,Zulfiya S Khodzhaeva,Gennady T Sukhikh

View all publications

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Anti-Blood Group Lewis y抗体[LWY/1463]

Anti-Blood Group Lewis y antibody [LWY/1463]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Blood Group Lewis y antibody [LWY/1463] (AB219336)

关键信息

宿主种属

克隆

克隆号

亚型

轻链类型

不含载体蛋白

反应种属

应用

免疫原