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AB84247

生物素Anti-TSLP抗体

Biotin Anti-TSLP antibody

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(1 Publication)

Anti-TSLP antibody conjugated to Biotin is a rabbit polyclonal antibody suitable for Western blot, sELISA, and reacts with human samples.

查看别名

Thymic stromal lymphopoietin, TSLP

1 Images
Sandwich ELISA - Biotin Anti-TSLP antibody (AB84247)
  • sELISA

Supplier Data

Sandwich ELISA - Biotin Anti-TSLP antibody (AB84247)

To detect human TSLP by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25 – 1.0 μg/mL of this antibody is required. This biotinylated polyclonal antibody, in conjunction with Rabbit polyclonal to TSLP (ab47943) as a capture antibody, allows the detection of at least 0.2 – 0.4 ng/well of recombinant human TSLP.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

偶联物

Biotin

激发波长/发射波长
不含载体蛋白

Yes

反应种属

Human

应用

WB, sELISA

applications

免疫原

Recombinant Full Length Protein corresponding to Human TSLP.

Q969D9

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替代产品

Primary Antibodies

AB47943

Anti-TSLP antibody

Western blot - Anti-TSLP antibody (AB47943)

  • 3
  • 1
Primary Antibodies

AB184638

Anti-TSLP antibody

Western blot - Anti-TSLP antibody (AB184638)

  • 0
  • 0
Primary Antibodies

AB229251

Anti-TSLP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSLP antibody (AB229251)

  • 0
  • 0
Primary Antibodies

AB115700

Anti-TSLP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSLP antibody (AB115700)

  • 0
  • 0
Primary Antibodies

AB188766

Anti-TSLP antibody

Western blot - Anti-TSLP antibody (AB188766)

  • 3
  • 1

搭配使用产品

Assay Kits

AB192149

Human TSLP ELISA Kit

SimpleStep

ELISA - Human TSLP ELISA Kit (AB192149)

  • 0
  • 0
Primary Antibodies

AB133741

Anti-Lamin B1 antibody [EPR8985(B)] - Nuclear Envelope Marker

RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Lamin B1 antibody [EPR8985(B)] - Nuclear Envelope Marker (AB133741)

  • 4
  • 15
Primary Antibodies

AB24955

Biotin Anti-IL-13 antibody [JES10-2E10]

  • 0
  • 0
Secondary Antibodies

AB205718

Goat Anti-Rabbit IgG H&L (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Rabbit IgG H&L (HRP) (AB205718)

  • 5
  • 8
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.2 µg/mL", "WB-species-notes": "<p>The detection limit for recombinant hTSLP is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.</p>", "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p>Use 100 μl/well antibody solution. Allows the detection of at least 0.2 – 0.4 ng/well of recombinant hTSLP.</p>" }, "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>The detection limit for recombinant hTSLP is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.</p>", "sELISA-species-checked": "notRecommended", "sELISA-species-dilution-info": "", "sELISA-species-notes": "" } } }
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性能和储存信息

形式
Lyophilized
复溶
Reconstitute in sterile PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
纯化工艺
Affinity purification Protein A
存储溶液
Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TSLP or thymic stromal lymphopoietin is a cytokine protein weighing around 27 kDa. It is also known as a hematopoietic cytokine and functions in the signaling processes of the immune system. TSLP is expressed in epithelial cells most notably in the skin lungs and gut. This cytokine holds significance due to its role in immune responses acting through its receptor complex made of TSLP receptor (TSLPR) and the interleukin-7 receptor alpha chain (IL-7Rα).
Biological function summary

TSLP plays a role in mediating immune system responses. It induces the differentiation of T-helper 2 (Th2) cells promoting a specific type of immune response. TSLP does not appear to be part of a larger protein complex but it often functions in association with the TSLPR and IL-7Rα receptor complex. It influences the activity and maturation of dendritic cells which are important for initiating immune responses.

Pathways

A mechanical understanding of TSLP reveals its involvement in both the JAK-STAT and NF-kB signaling pathways. It interacts with proteins like JAK2 and STAT5 which are important for the downstream signaling cascade leading to inflammation and immune responses. These pathways play important roles in the immune system's ability to detect and respond to environmental triggers.

TSLP has relevance in conditions like asthma and atopic dermatitis. It promotes inflammation that contributes to these allergic diseases. The dysregulation of TSLP expression can exacerbate these conditions. In asthma TSLP interacts with proteins such as interleukin-33 (IL-33) to enhance inflammatory responses in airway tissues. In atopic dermatitis connections with interleukin-4 (IL-4) are noted as both cytokines contribute to the inflammatory processes involved in the disease pathology. These associations make TSLP a potential target for therapeutic interventions in such disorders.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Isoform 1. Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.. Isoform 2. May act as an antimicrobial peptide in the oral cavity and on the skin.
See full target information TSLP
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 10:e0117038 PubMed25643281

2015

Antimicrobial protein and Peptide concentrations and activity in human breast milk consumed by preterm infants at risk of late-onset neonatal sepsis.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie Trend,Tobias Strunk,Julie Hibbert,Chooi Heen Kok,Guicheng Zhang,Dorota A Doherty,Peter Richmond,David Burgner,Karen Simmer,Donald J Davidson,Andrew J Currie
View all publications
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