AB77310

Biotin Anti-Prostate Specific Antigen 抗体 [A67-B/E3]

Name: Biotin Anti-Prostate Specific Antigen抗体[A67-B/E3] (ab77310)| Abcam中文官网
Brand: Abcam Limited
SKU: AB77310
Price: 4677 CNY
Availability: InStock

Biotin Anti-Prostate Specific Antigen antibody [A67-B/E3]

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(2 Publications)

Mouse Monoclonal Prostate Specific Antigen antibody - conjugated to Biotin. Suitable for ELISA, WB and reacts with Human samples. Cited in 2 publications.

查看别名

APS, KLK3, Prostate-specific antigen, PSA, Gamma-seminoprotein, Kallikrein-3, P-30 antigen, Semenogelase, Seminin

不同偶联物与剂型 (2)

Carrier free

Anti-Prostate Specific Antigen antibody [A67-B/E3] - BSA and Azide free
Unconjugated

Anti-Prostate Specific Antigen antibody [A67-B/E3]

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

A67-B/E3

亚型

IgG1

偶联物

Biotin

激发波长/发射波长

不含载体蛋白

反应种属

Human

应用

WB, ELISA

applications

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

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产品详情

Purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

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性能和储存信息

形式

Liquid

纯化工艺

Size-exclusion chromatography

存储溶液

pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS

运输条件

Blue Ice

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Prostate Specific Antigen (PSA) also known as kallikrein-related peptidase 3 (KLK3) is a serine protease with a mass of approximately 28.4 kDa. PSA is primarily expressed in the epithelial cells of the prostate gland. This glycoprotein is an important component in the seminal fluid where it performs its proteolytic activity that liquefies semen facilitating sperm motility.

Biological function summary

PSA functions by cleaving the gel-forming proteins present in seminal coagulum. It does not operate as part of a larger protein complex. PSA also interacts with substrates like fibronectin and semenogelin which play roles in seminal coagulation and liquefaction. The expression of PSA in prostate tissue has made it a valuable biomarker for prostate function and pathological conditions.

Pathways

PSA is involved in the kallikrein-kinin system which influences inflammation and blood pressure regulation. PSA is not directly a part of key metabolic or signaling pathways but it is co-expressed with key proteins like androgen receptor (AR) which modulates PSA's expression. The interplay between androgens and PSA highlights its role in hormone regulation within the male reproductive system.

PSA levels serve as an indicator for prostate cancer and benign prostatic hyperplasia (BPH). Elevated PSA levels often correlate with prostate cancer although other prostate conditions such as prostatitis can also increase PSA without cancer. Proteins like PCA3 and the AR are also connected in the context of prostate cancer providing a broader understanding of PSA's role in these diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

See full target information KLK3

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

PloS one 10:e0117744 PubMed25680117

2015

A microfluidic platform for high-throughput multiplexed protein quantitation.

Applications

Unspecified application

Species

Unspecified reactive species

Francesca Volpetti,Jose Garcia-Cordero,Sebastian J Maerkl

Analytical chemistry 84:5518-23 PubMed22632629

2012

Streamlining immunoassays with immiscible filtrations assisted by surface tension.

Applications

FuncS

Species

Human

Scott M Berry,Lindsey J Maccoux,David J Beebe

View all publications

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Biotin Anti-Prostate Specific Antigen 抗体 [A67-B/E3]