生物素Anti-Nitro tyrosine抗体[HM.11] (ab7225)
Key features and details
- Biotin Mouse monoclonal [HM.11] to Nitro tyrosine
- Suitable for: IHC-P
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG2b
Related conjugates and formulations
概述
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产品名称
生物素Anti-Nitro tyrosine抗体[HM.11]
参阅全部 Nitro tyrosine 一抗 -
描述
生物素小鼠单克隆抗体[HM.11] to Nitro tyrosine -
宿主
Mouse -
偶联物
Biotin -
特异性
This highly specific monoclonal antibody reacts with nitrotyrosine, both with the free amino acid as well as with proteins containing nitrotyrosine. -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.60
Constituents: 0.164% Sodium phosphate, 1.45% Sodium chloride, 1.5% BSA -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
HM.11 -
同种型
IgG2b -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
1/200 - 1/400.
|
说明 |
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IHC-P
1/200 - 1/400. |
靶标
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相关性
Nitric oxide (NO) is a product of the enzymatic conversion of arginine to citrulline by nitric oxide synthase. NO reacts rapidly with superoxide to form peroxynitrite. At physiological pH and in the presence of transition metals, peroxynitrite undergoes heterolytic cleavage to form hydroxyl anion and nitronium ion, the latter of which nitrates protein tyrosine residues. Thus, the presence of nitrotyrosine on proteins can be used as a marker for peroxynitrite formation in vivo. The presence of nitrotyrosine has been detected in various inflammatory processes including atherosclerotic placques. -
别名
- NO tyrosine antibody
- nTyr antibody
图片
数据表及文件
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Datasheet download
文献 (2)
ab7225 被引用在 2 文献中.
- Hathuc C et al. Nitration of human plasminogen by RAW 264.7 macrophages reduces streptokinase-induced plasmin activity. Clin Chem Lab Med 44:213-9 (2006). WB . PubMed: 16475910
- Bixby M et al. Ilex paraguariensis extracts are potent inhibitors of nitrosative stress: a comparative study with green tea and wines using a protein nitration model and mammalian cell cytotoxicity. Life Sci 77:345-58 (2005). WB . PubMed: 15878361