AB25680

生物素Anti-Ly6g抗体[RB6-8C5]

Biotin Anti-Ly6g antibody [RB6-8C5]

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(14 Publications)

Rat Monoclonal Ly6g antibody - conjugated to Biotin. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 14 publications.

查看别名

Lymphocyte antigen 6G, Ly-6G, Ly-6G.1, Ly6g

1 Images

Flow Cytometry - Biotin Anti-Ly6g antibody [RB6-8C5] (AB25680)

Flow Cyt

Supplier Data

Flow Cytometry - Biotin Anti-Ly6g antibody [RB6-8C5] (AB25680)

Flow Cytometry analysis of C57Bl/6 bone marrow cells labeling Ly6g with ab25680 at 0.06μg (right panel) or Rat IgG2b (Biotin) isotype control (left panel) followed by Streptavidin FITC.

关键信息

宿主种属

Rat

克隆

Monoclonal

克隆号

RB6-8C5

亚型

IgG2b

轻链类型

kappa

偶联物

Biotin

激发波长/发射波长

不含载体蛋白

反应种属

Mouse

应用

Flow Cyt

applications

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/biotin-rat-igg2b-kappa-monoclonal-rtk4530-isotype-control-ab18542'>ab18542</a> - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification

纯化说明

Purified from TCS

存储溶液

pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.14% Sodium dihydrogen phosphate, 0.1% Gelatin

运输条件

Blue Ice

储存信息

Do Not Freeze|Store undiluted

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Ly6G also known as lymphocyte antigen 6 complex locus G6D 1A8 or 8C5 is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein. The molecule has a molecular weight of about 25-30 kDa. Its expression is mainly on neutrophils and a subpopulation of eosinophils in mice. It plays a role in the innate immune system marking these immune cells for differentiation and response to infection. Researchers consider it a specific marker for detecting and isolating mouse neutrophils often using methods such as Ly6G staining or anti-Ly6G antibodies for identification.

Biological function summary

Ly6G functions in the immune response by facilitating the migration and adhesion of neutrophils to the site of infection or injury. It is part of a protein complex on the cell surface that includes other Ly6 proteins. This group of proteins helps to modulate signal transduction for immune cell functions. Ly6G serves as an anchor through its GPI linkage aiding cell-to-cell communication and signal amplification in inflammation processes.

Pathways

Ly6G is significantly integrated into the immune signaling pathways notably the toll-like receptor (TLR) signaling pathway. Through these pathways Ly6G influences neutrophil migration and activation. Closely associated proteins include CD11b and CD18 which interact with Ly6G in neutrophil functions including adhesion and transmigration. These pathways are essential for orchestrating the body's defense mechanisms against pathogens.

Ly6G plays an essential role in inflammatory conditions and autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Aberrant expression or function of Ly6G can alter neutrophil behavior which contributes to disease pathology. Researchers are investigating the relationship between Ly6G and other immune-related proteins like myeloperoxidase (MPO) and elastase as these protein interactions may impact the development and progression of inflammatory diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information Ly6g

其他靶点

Ly6c1

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文献 (14)

Recent publications for all applications. Explore the full list and refine your search

Immunity 51:258-271.e5 PubMed31350176

2019

The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew S Kimball,Frank M Davis,Aaron denDekker,Amrita D Joshi,Matthew A Schaller,Jennifer Bermick,Xianying Xing,Charles F Burant,Andrea T Obi,Dylan Nysz,Scott Robinson,Ron Allen,Nicholas W Lukacs,Peter K Henke,Johann E Gudjonsson,Bethany B Moore,Steve L Kunkel,Katherine A Gallagher

Clinical cancer research : an official journal of 24:6015-6027 PubMed30262507

2018

A Designer Cross-reactive DNA Immunotherapeutic Vaccine that Targets Multiple MAGE-A Family Members Simultaneously for Cancer Therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Elizabeth K Duperret,Shujing Liu,Megan Paik,Aspen Trautz,Regina Stoltz,Xiaoming Liu,Kan Ze,Alfredo Perales-Puchalt,Charles Reed,Jian Yan,Xiaowei Xu,David B Weiner

Oncogene 34:3556-67 PubMed25195861

2014

The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase.

Applications

Unspecified application

Species

Unspecified reactive species

J A Caruso,S Akli,L Pageon,K K Hunt,K Keyomarsi

Journal of immunological methods 197:139-50 PubMed8890901

1996

Flow cytometric identification of murine neutrophils and monocytes.

Applications

Unspecified application

Species

Unspecified reactive species

E Lagasse,I L Weissman

Journal of virology 70:898-904 PubMed8551629

1996

Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea.

Applications

Unspecified application

Species

Unspecified reactive species

T M Tumpey,S H Chen,J E Oakes,R N Lausch

Journal of leukocyte biology 57:827-31 PubMed7790763

1995

Neutrophils are essential for resolution of primary and secondary infection with Listeria monocytogenes.

Applications

Unspecified application

Species

Unspecified reactive species

A L Rakhmilevich

Journal of immunology (Baltimore, Md. : 1950) 152:1836-46 PubMed8120393

1994

Administration of anti-granulocyte mAb RB6-8C5 impairs the resistance of mice to Listeria monocytogenes infection.

Applications

Unspecified application

Species

Unspecified reactive species

C J Czuprynski,J F Brown,N Maroushek,R D Wagner,H Steinberg

The Journal of experimental medicine 179:259-68 PubMed8270870

1994

Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody.

Applications

Unspecified application

Species

Unspecified reactive species

J W Conlan,R J North

Journal of immunology (Baltimore, Md. : 1950) 151:2399-408 PubMed8360469

1993

Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family.

Applications

Unspecified application

Species

Unspecified reactive species

T J Fleming,M L Fleming,T R Malek

The Journal of experimental medicine 178:151-61 PubMed7686211

1993

Regression of an established tumor genetically modified to release granulocyte colony-stimulating factor requires granulocyte-T cell cooperation and T cell-produced interferon gamma.

Applications

Unspecified application

Species

Unspecified reactive species

A Stoppacciaro,C Melani,M Parenza,A Mastracchio,C Bassi,C Baroni,G Parmiani,M P Colombo

View all publications

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生物素Anti-Ly6g抗体[RB6-8C5]

Biotin Anti-Ly6g antibody [RB6-8C5]

Flow Cytometry - Biotin Anti-Ly6g antibody [RB6-8C5] (AB25680)

关键信息

宿主种属

克隆

克隆号

亚型

轻链类型

偶联物

激发波长/发射波长

不含载体蛋白

反应种属

应用