生物素Anti-Lipoprotein a抗体(ab27631)
Key features and details
- Biotin Sheep polyclonal to Lipoprotein a
- Suitable for: ELISA, ICC/IF, WB
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG
概述
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产品名称
生物素Anti-Lipoprotein a抗体
参阅全部 Lipoprotein a 一抗 -
描述
生物素羊多克隆抗体to Lipoprotein a -
宿主
Sheep -
偶联物
Biotin -
特异性
Thsi antibody specifically binds to human Lipoprotein a. -
经测试应用
适用于: ELISA, ICC/IF, WBmore details -
种属反应性
与反应: Human -
免疫原
Full length native Lipoprotein a protein (purified) (Human)
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 0.2% PBS, 0.435% Sodium chloride -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
Purified by a human plasminogen-Sepharose affinity column to remove cross-reactivity to plasminogen, followed by a Apolipoprotein A-Sepharose affinity column. -
克隆
多克隆 -
同种型
IgG -
研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab27631于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| ICC/IF |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration.
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| 说明 |
|---|
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ELISA
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
靶标
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相关性
Lipoprotein(a) (Lp(a)) is a lipoprotein subclass assembled in the blood from low density lipoprotein (LDL) molecules and apolipoprotein-a (apo-a). Lp(a) recruits inflammatory cells through interaction with Mac-1 integrin. High Lp(a) in blood is a risk factor for coronary heart disease, cerebrovascular disease, atherosclerosis, thrombosis, and stroke. Lp(a) concentrations may be affected by disease states, but are only moderately affected by diet, exercise and other environmental factors. Lipid-reducing drugs have no effect on Lp(a) concentration. High Lp(a) predicts risk of early atherosclerosis similar to high LDL, but in advanced atherosclerosis, Lp(a) is a risk factor independent of LDL, indicating a coagulant risk of plaque thrombosis. Apo(a) contains domains that are very similar to plasminogen (PLG). Lp(a) accumulates in the vessel wall and inhibits binding of PLG to the cell surface, reducing plasmin generation which increases clotting. This inhibition also promotes proliferation of smooth muscle cells. These unique features of Lp(a) suggest a role in the generation of clots and atherosclerosis. -
数据库链接
- Entrez Gene: 4018 Human
- Omim: 152200 Human
- SwissProt: P08519 Human
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别名
- AK38 antibody
- Antiangiogenic AK38 protein antibody
- apo(a) antibody
see all
数据表及文件
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Datasheet download
文献 (2)
ab27631 被引用在 2 文献中.
- Konishi T et al. Human lipoproteins comprise at least 12 different classes that are lognormally distributed. PLoS One 17:e0275066 (2022). PubMed: 36355715
- Giesecke Y et al. Developing Electron Microscopy Tools for Profiling Plasma Lipoproteins Using Methyl Cellulose Embedment, Machine Learning and Immunodetection of Apolipoprotein B and Apolipoprotein(a). Int J Mol Sci 21:N/A (2020). PubMed: 32887372
