生物素Anti-IL-6抗体[B-E4] (ab281337)
Key features and details
- Biotin Mouse monoclonal [B-E4] to IL-6
- Suitable for: ELISA
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG2b
Related conjugates and formulations
概述
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产品名称
生物素Anti-IL-6抗体[B-E4]
参阅全部 IL-6 一抗 -
描述
生物素小鼠单克隆抗体[B-E4] to IL-6 -
宿主
Mouse -
偶联物
Biotin -
经测试应用
适用于: ELISAmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein corresponding to Human IL-6.
Database link: P05231 -
常规说明
ab281337 can be used as Detection in a human sandwich Immunoassay. The suggested coating concentration range should be optimised by each laboratory for each application.
ab281337 recognises both natural and recombinant Human IL-6.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark. -
存储溶液
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 1% BSA, 98.91% PBS -
Concentration information loading... -
纯化说明
Purified from tissue culture supernatant. -
克隆
单克隆 -
克隆编号
B-E4 -
骨髓瘤
x63-Ag8.653 -
同种型
IgG2b -
轻链类型
kappa -
研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab281337于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
Use a concentration of 0.05 - 0.5 µg/ml.
|
| 说明 |
|---|
|
ELISA
Use a concentration of 0.05 - 0.5 µg/ml. |
靶标
-
功能
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. -
疾病相关
Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. -
序列相似性
Belongs to the IL-6 superfamily. -
翻译后修饰
N- and O-glycosylated. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 3569 Human
- Omim: 147620 Human
- SwissProt: P05231 Human
- Unigene: 654458 Human
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别名
- Interleukin BSF 2 antibody
- B cell differentiation factor antibody
- B cell stimulatory factor 2 antibody
see all
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab281337 尚未被引用在任何文献中。