Key features and details
- Biotin Mouse monoclonal [IgA5-3B] to IgA
- Suitable for: ELISA
- Reacts with: Cat, Dog, Human, Rhesus monkey, Common marmoset
- Conjugation: Biotin
- Isotype: IgG1
参阅全部 IgA 一抗
描述生物素小鼠单克隆抗体[IgA5-3B] to IgA
特异性ab53270 recognises IgA. It does not cross-react with IgG or IgM; it has been shown to detect secreted IgA in cat saliva and rhesus monkey jejunal washes
经测试应用适用于: ELISAmore details
种属反应性与反应: Cat, Dog, Human, Rhesus monkey, Common marmoset
Purified monkey IgA, from serum.
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.05% Sodium azide
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纯度Protein A purified
纯化说明ab53270 is prepared by affinity chromatography on Protein A from tissue culture supernatant.
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Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
相关性Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA. OR: The secretory component is a component of immunoglobulin A (IgA) which consists of a portion of the polymeric immunoglobulin receptor. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen.
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To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.