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生物素Anti-Factor V抗体(ab48230)

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Key features and details

  • Biotin Rabbit polyclonal to Factor V
  • Suitable for: ELISA
  • Reacts with: Human
  • Conjugation: Biotin
  • Isotype: IgG

概述

  • 产品名称

    生物素Anti-Factor V抗体
    参阅全部 Factor V 一抗

  • 描述

    生物素兔多克隆抗体to Factor V

  • 宿主

    Rabbit

  • 偶联物

    Biotin

  • 经测试应用

    适用于: ELISAmore details

  • 种属反应性

    与反应: Human

  • 免疫原

    Full length native Factor V purified from plasma (Human).

  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

  • 形式

    Liquid

  • 存放说明

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • 存储溶液

    pH: 7.50
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...

  • 纯度

    Protein G purified

  • 克隆

    多克隆

  • 同种型

    IgG

  • 研究领域

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab48230于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
ELISA
Use at an assay dependent concentration.

The antibody sensitivity is at 0.7 pg/ml.
说明
ELISA
Use at an assay dependent concentration.

The antibody sensitivity is at 0.7 pg/ml.

靶标

  • 功能

    Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.

  • 组织特异性

    Plasma.

  • 疾病相关

    Factor V deficiency
    Thrombophilia due to activated protein C resistance
    Budd-Chiari syndrome
    Ischemic stroke
    Pregnancy loss, recurrent, 1

  • 序列相似性

    Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 2 F5/8 type C domains.
    Contains 6 plastocyanin-like domains.

  • 结构域

    Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.

  • 翻译后修饰

    Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
    Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
    Activated protein C inactivates factor V and factor Va by proteolytic degradation.
    Phosphorylation sites are present in the extracellular medium.

  • 细胞定位

    Secreted.
  • Information by UniProt

  • 数据库链接

    • 别名

      • Activated protein C cofactor antibody
      • APC cofactor antibody
      • coagulation factor V (proaccelerin, labile factor) antibody
      • Coagulation factor V antibody
      • coagulation factor V jinjiang A2 domain antibody
      • Coagulation factor V light chain antibody
      • F5 antibody
      • FA5_HUMAN antibody
      • Factor V Leiden antibody
      • FactorV antibody
      • FVL antibody
      • Labile factor antibody
      • PCCF antibody
      • Proaccelerin antibody
      • proaccelerin, labile factor antibody
      • Protein C cofactor antibody
      • RPRGL1 antibody
      • THPH2 antibody
      see all

    文献 (0)

    发表研究结果有使用 ab48230？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab48230 尚未被引用在任何文献中。

    客户评价及客户问答

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    Question

    I have a few questions on the anti-FV antibodies you offer:
    -anti-FV antibody (Biotin) ab48230: has it been tested whether thisantibody recognizes activated FV (FVa) and/or activated FV products?
    Also, is it known whether this antibody cross reacts with species other than human FV?
    -anti-FV antibody ab61368: has it been tested whether this antibodyrecognizes activated bovine FV (FVa) and/or activated bovine FV products? Also, is it known whether this antibody cross reacts with species other than bovine FV?
    -anti-FV antibody ab21037:is it known whether this antibody cross reacts with species other than human FV?
    I'm looking for an antiFV antibody that is highly cross reactive and nonspecific, hence my questions.
    Many thanks,

    Read More
    Answer

    First of all I would like to apologise for the delay in getting back to you.I really appreciate your patience and comprehension.

    -In regards to antibody ab21037, I am afraid it has only been tested against human factor V, therefore it is unknown whether it could cross react with other species.

    - Product ab61368 is a polyclonal antibody and it may bind to multiple epitopes, recognising the activated protein as well. The only other species we have tested against for cross reactivity is human and it cross reacts very weakly.

    -Regarding ab48230, this antibody can recognize FVa and it has not been tested against other species yet.

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Read More

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