生物素Anti-CD44抗体[MEM-85] (ab28105)
![Flow Cytometry - Biotin Anti-CD44 antibody [MEM-85] (ab28105)](https://www.abcam.cn/ps/products/28/ab28105/Images/ab28105-273624-anti-cd44-antibody-mem-85-biotin-flow-cytometry.jpg "Flow Cytometry - Biotin Anti-CD44 antibody [MEM-85] (ab28105)")
Key features and details
- Biotin Mouse monoclonal [MEM-85] to CD44
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG2b
概述
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产品名称
生物素Anti-CD44抗体[MEM-85]
参阅全部 CD44 一抗 -
描述
生物素小鼠单克隆抗体[MEM-85] to CD44 -
宿主
Mouse -
偶联物
Biotin -
特异性
The antibody reacts with both cell surface-expressed and soluble form of CD44 antigen. -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to Human CD44. Leucocytes of a patient suffering from LGL Type Leukaemia
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阳性对照
- Flow Cyt: human peripheral blood
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常规说明
The purified antibody is conjugated with Biotin-LC-NHS.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.097% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
MEM-85 -
同种型
IgG2b -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab28105于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
Use a concentration of 1 - 3 µg/ml.
ab18418 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
| 说明 |
|---|
|
Flow Cyt
Use a concentration of 1 - 3 µg/ml. ab18418 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. -
组织特异性
Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. -
序列相似性
Contains 1 Link domain. -
结构域
The lectin-like LINK domain is responsible for hyaluronan binding. -
翻译后修饰
Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
N-glycosylated.
O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s).
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 960 Human
- Omim: 107269 Human
- SwissProt: P16070 Human
- Unigene: 502328 Human
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别名
- LHR antibody
- BA-1 antibody
- CD 44 antibody
see all
图片
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Flow Cytometry - Biotin Anti-CD44 antibody [MEM-85] (ab28105)
Analysis by flow cytometry of ab28105 staining CD44 in human peripheral blood leukocytes.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab28105 尚未被引用在任何文献中。