生物素Anti-CD33抗体[HIM3-4] (ab21892)
![Flow Cytometry - Biotin Anti-CD33 antibody [HIM3-4] (ab21892)](https://www.abcam.cn/ps/products/21/ab21892/Images/ab21892-278888-anti-cd33-antibody-him3-4-biotin-flow-cytometry.jpg "Flow Cytometry - Biotin Anti-CD33 antibody [HIM3-4] (ab21892)")
Key features and details
- Biotin Mouse monoclonal [HIM3-4] to CD33
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG1
概述
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产品名称
生物素Anti-CD33抗体[HIM3-4]
参阅全部 CD33 一抗 -
描述
生物素小鼠单克隆抗体[HIM3-4] to CD33 -
宿主
Mouse -
偶联物
Biotin -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to CD33. Human cell line NFMY-9s
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常规说明
The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.097% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Protein G purified -
纯化说明
antibody purified. -
克隆
单克隆 -
克隆编号
HIM3-4 -
同种型
IgG1 -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab21892于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
Use a concentration of 1 - 12 µg/ml.
ab18434 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
| 说明 |
|---|
|
Flow Cyt
Use a concentration of 1 - 12 µg/ml. ab18434 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). -
组织特异性
Monocytic/myeloid lineage cells. -
序列相似性
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
结构域
Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. -
翻译后修饰
Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 945 Human
- Omim: 159590 Human
- SwissProt: P20138 Human
- Unigene: 83731 Human
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别名
- CD 33 antibody
- CD33 antibody
- CD33 antigen (gp67) antibody
see all
图片
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Flow Cytometry - Biotin Anti-CD33 antibody [HIM3-4] (ab21892)Flow Cytometry analysis of human peripheral blood cells labeling CD33 with Anti-CD33 antibody [HIM3-4] (Biotin) (ab21892).
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab21892 尚未被引用在任何文献中。