生物素Anti-BAFF-R抗体[11C1] (ab16582)
Key features and details
- Biotin Mouse monoclonal [11C1] to BAFF-R
- Suitable for: IHC-Fr, IHC (PFA fixed), Flow Cyt
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG1
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
生物素Anti-BAFF-R抗体[11C1]
参阅全部 BAFF-R 一抗 -
描述
生物素小鼠单克隆抗体[11C1] to BAFF-R -
宿主
Mouse -
偶联物
Biotin -
经测试应用
适用于: IHC-Fr, IHC (PFA fixed), Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to Human BAFF-R. Transfected mouse B cell lymphoma L1.2 cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading... -
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
11C1 -
骨髓瘤
Sp2/0 -
同种型
IgG1 -
研究领域
相关产品
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab16582于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr | ||
| IHC (PFA fixed) | ||
| Flow Cyt |
| 说明 |
|---|
IHC-P: Use at an assay dependent dilution. Antigen retrieval with EDTA based solution (pH9.0) and heat.
IHC-Fr: Use at an assay dependent dilution.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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功能
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. -
组织特异性
Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. -
疾病相关
Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. -
序列相似性
Contains 1 TNFR-Cys repeat. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 115650 Human
- Omim: 606269 Human
- SwissProt: Q96RJ3 Human
- Unigene: 344088 Human
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别名
- B cell activating factor receptor antibody
- B-cell-activating factor receptor antibody
- BAFF R antibody
see all
实验方案
数据表及文件
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Datasheet download
文献 (2)
ab16582 被引用在 2 文献中.
- Xu H et al. Abnormally high expression of BAFF on T lymphocytes from lung cancer-associated pleural effusions and its potent anti-tumor effect. Acta Biochim Biophys Sin (Shanghai) 39:964-73 (2007). Flow Cyt ; Human . PubMed: 18064389
- Ng LG et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 173:807-17 (2004). PubMed: 15240667
