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AB84029

生物素Anti-APRIL/TNFSF13抗体

Biotin Anti-APRIL/TNFSF13 antibody

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(1 Publication)

Anti-APRIL/TNFSF13 antibody conjugated to Biotin is a rabbit polyclonal antibody suitable for Western blot, sELISA, and reacts with human samples.

查看别名

CD256, APRIL, TALL2, ZTNF2, UNQ383/PRO715, TNFSF13, Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand, TNF- and APOL-related leukocyte expressed ligand 2, TNF-related death ligand 1, TALL-2, TRDL-1

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

偶联物

Biotin

激发波长/发射波长
不含载体蛋白

No

反应种属

Human

应用

sELISA, WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human TNFSF13.

O75888

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替代产品

Primary Antibodies

AB108206

Anti-APRIL/TNFSF13 antibody [EPR4286]

RabMAb|Recombinant

Western blot - Anti-APRIL/TNFSF13 antibody [EPR4286] (AB108206)

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Primary Antibodies

AB189263

Anti-APRIL/TNFSF13 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APRIL/TNFSF13 antibody (AB189263)

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搭配使用产品

Assay Kits

AB119505

Human APRIL ELISA Kit

Sandwich ELISA - Human APRIL ELISA Kit (AB119505)

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Proteins & Peptides

AB50096

Recombinant mouse APRIL/TNFSF13 protein

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Proteins & Peptides

AB283485

Recombinant Human BAFF protein (Active)

Premium Bioactive

Functional Studies - Recombinant Human BAFF protein (Active) (AB283485)

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Primary Antibodies

AB271214

Biotin Anti-BAFF antibody

ELISA - Biotin Anti-BAFF antibody (AB271214)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Lyophilized
复溶
Centrifuge vial prior to opening. Reconstitute in 50 µl sterile PBS containing 0.1% BSA to give a concentration of 1.0 mg/ml.
纯化工艺
Affinity purification Protein A
纯化说明
ab84029 is a sterile filtered antibody solution.
存储溶液
Constituents: PBS, 0.1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

APRIL also known as TNFSF13 is a member of the tumor necrosis factor (TNF) ligand superfamily. This protein has a mass of approximately 31 kDa and undergoes incorporation into different cellular processes. APRIL is mainly expressed in cells of the immune system such as T cells B cells and myeloid cells. The protein plays a critical role in modulating various biological activities including cell survival proliferation and apoptosis.
Biological function summary

APRIL functions as a cytokine involved in immune regulation. The molecule acts independently or as part of a ligand-receptor interaction binding specifically to receptors like BCMA and TACI. This interaction influences B-cell maturation and differentiation driving immune responses. APRIL helps maintain homeostasis within the immune system ensuring appropriate immune activation and preventing overactive immune responses.

Pathways

APRIL coordinates with several immune-related pathways notably the B-cell signaling pathway and the NF-kB signaling pathway. These pathways are essential in immune system modulation influencing how the body responds to pathogens. APRIL interacts with proteins such as BAFF (B-cell activating factor) which share common receptors shaping the immune response through these pathways and ensuring proper immune cell function.

APRIL has connections with conditions like autoimmune diseases and certain lymphomas. Elevated levels of APRIL often occur in diseases like lupus contributing to abnormal B-cell activity and autoantibody production. Additionally its involvement in lymphomas links to excessive proliferation of B cells. Proteins such as BAFF and their receptors play a significant role in these conditions highlighting APRIL's impact on disease mechanisms and potential as a therapeutic target.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
See full target information TNFSF13
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 14:125 PubMed36792587

2023

NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via mC methylation.

Applications

Unspecified application

Species

Unspecified reactive species

Min Yang,Renxiong Wei,Sheng Zhang,Sang Hu,Xiaoxiao Liang,Zhiqiang Yang,Chong Zhang,Yufeng Zhang,Lin Cai,Yuanlong Xie
View all publications
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