生物素Anti-Antithrombin III/ATIII抗体(ab79933)
Key features and details
- Biotin Rabbit polyclonal to Antithrombin III/ATIII
- Suitable for: ELISA, RIA, WB
- Reacts with: Mouse
- Conjugation: Biotin
- Isotype: IgG
概述
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产品名称
生物素Anti-Antithrombin III/ATIII抗体
参阅全部 Antithrombin III/ATIII 一抗 -
描述
生物素兔多克隆抗体to Antithrombin III/ATIII -
宿主
Rabbit -
偶联物
Biotin -
经测试应用
适用于: ELISA, RIA, WBmore details -
种属反应性
与反应: Mouse -
免疫原
Full length native protein (purified) corresponding to Mouse Antithrombin III/ATIII.
Database link: P32261 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.25% BSA -
Concentration information loading... -
纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab79933于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA | ||
| RIA | ||
| WB |
| 说明 |
|---|
RIA: Use at a concentration of 4 µg/ml.
WB: Use at an assay dependent dilution. Predicted molecular weight: 52 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
-
功能
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. -
组织特异性
Found in plasma. -
疾病相关
Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. -
序列相似性
Belongs to the serpin family. -
翻译后修饰
Phosphorylation sites are present in the extracelllular medium. -
细胞定位
Secreted > extracellular space. - Information by UniProt
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数据库链接
- Entrez Gene: 11905 Mouse
- SwissProt: P32261 Mouse
- Unigene: 260770 Mouse
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别名
- ANT3_HUMAN antibody
- Antithrombin antibody
- Antithrombin III antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab79933 被引用在 1 文献中.
- Hansen CB et al. The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema. J Immunol 195:3596-604 (2015). PubMed: 26371246