生物素Anti-alpha 2 Macroglobulin抗体(ab7338)
Key features and details
- Biotin Goat polyclonal to alpha 2 Macroglobulin
- Suitable for: ELISA, IHC-Fr, IP, Dot blot, Immunomicroscopy, WB
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG
概述
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产品名称
生物素Anti-alpha 2 Macroglobulin抗体
参阅全部 alpha 2 Macroglobulin 一抗 -
描述
生物素山羊多克隆抗体to alpha 2 Macroglobulin -
宿主
Goat -
偶联物
Biotin -
经测试应用
适用于: ELISA, IHC-Fr, IP, Dot blot, Immunomicroscopy, WBmore details -
种属反应性
与反应: Human -
免疫原
Full length native protein (purified) corresponding to Human alpha 2 Macroglobulin.
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常规说明
Biotinamidocaproate N-Hydroxysuccinimide Ester (BAC) Biotin/Protein Ratio: 10-20 BAC molecules per rabbit IgG molecule.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.01% Sodium azide
Constituents: 0.88% Sodium chloride, 1% BSA, 0.42% Potassium phosphate -
Concentration information loading... -
纯度
IgG fraction -
纯化说明
This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Isotype control
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Recombinant Protein
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA | ||
| IHC-Fr | ||
| IP | ||
| Dot blot | ||
| Immunomicroscopy | ||
| WB |
| 说明 |
|---|
ELISA (1:9,000 to 1:36,000)
Immunohistochemistry
Immunomicroscopy
as well as other antibody based assays using streptavidin or avidin conjugates requiring lot-to-lot consistency.
靶标
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功能
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. -
组织特异性
Secreted in plasma. -
序列相似性
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. -
发展阶段
Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 2 Human
- Omim: 103950 Human
- SwissProt: P01023 Human
- Unigene: 212838 Human
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别名
- A2m antibody
- A2MG_HUMAN antibody
- Alpha 2 M antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab7338 被引用在 1 文献中.
- Jensen PE et al. Significantly increased fractions of transformed to total alpha2-macroglobulin concentrations in plasma from patients with multiple sclerosis. Biochim Biophys Acta 1690:203-7 (2004). ELISA . PubMed: 15511627