生物素Anti-alpha 2 Macroglobulin抗体(ab7338)
Key features and details
- Biotin Goat polyclonal to alpha 2 Macroglobulin
- Suitable for: ELISA, IHC-Fr, IP, Dot blot, Immunomicroscopy, WB
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG
产品名称生物素Anti-alpha 2 Macroglobulin抗体
参阅全部 alpha 2 Macroglobulin 一抗
描述生物素山羊多克隆抗体to alpha 2 Macroglobulin
经测试应用适用于: ELISA, IHC-Fr, IP, Dot blot, Immunomicroscopy, WBmore details
Full length native protein (purified) corresponding to Human alpha 2 Macroglobulin.
Biotinamidocaproate N-Hydroxysuccinimide Ester (BAC) Biotin/Protein Ratio: 10-20 BAC molecules per rabbit IgG molecule.
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
存储溶液Preservative: 0.01% Sodium azide
Constituents: 0.88% Sodium chloride, 1% BSA, 0.42% Potassium phosphate
Concentration information loading...
纯化说明This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer.
The Abpromise guarantee
ELISA (1:9,000 to 1:36,000)
as well as other antibody based assays using streptavidin or avidin conjugates requiring lot-to-lot consistency.
功能Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
组织特异性Secreted in plasma.
序列相似性Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
发展阶段Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.
- Information by UniProt
- Entrez Gene: 2 Human
- Omim: 103950 Human
- SwissProt: P01023 Human
- Unigene: 212838 Human
- A2m antibody
- A2MG_HUMAN antibody
- Alpha 2 M antibody
ab7338 被引用在 1 文献中.
- Jensen PE et al. Significantly increased fractions of transformed to total alpha2-macroglobulin concentrations in plasma from patients with multiple sclerosis. Biochim Biophys Acta 1690:203-7 (2004). ELISA . PubMed: 15511627