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Anti-beta Endorphin抗体[B 31.15] (ab54205)

Submit a review Q&A (2)References (4)

Key features and details

  • Mouse monoclonal [B 31.15] to beta Endorphin
  • Suitable for: IHC-Fr, IHC-P
  • Reacts with: Rat, Human, Macaque monkey
  • Isotype: IgG1

概述

  • 产品名称

    Anti-beta Endorphin抗体[B 31.15]

  • 描述

    小鼠单克隆抗体[B 31.15] to beta Endorphin

  • 宿主

    Mouse

  • 经测试应用

    适用于: IHC-Fr, IHC-Pmore details

  • 种属反应性

    与反应: Rat, Human, Macaque monkey

  • 免疫原

    Full length native human beta Endorphin.

  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab54205于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
IHC-Fr
Use at an assay dependent concentration.
IHC-P
Use at an assay dependent concentration.
说明
IHC-Fr
Use at an assay dependent concentration.
IHC-P
Use at an assay dependent concentration.

靶标

  • 相关性

    Beta-endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system. ß-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor pro-opiomelanocortin (POMC). ß-endorphin is found in neurons of the hypothalamus as well as the pituitary gland. It is an agonist of the opioid receptors, with evidence suggesting that it serves as the endogenous ligand of the µ-opioid receptor, the same receptor to which the chemicals extracted from opium, such as morphine and codeine, have their analgesic and addictive effects

  • 细胞定位

    Secreted

  • 数据库链接

    • 别名

      • Beta endorphin antibody
      • Corticotropin lipotropin antibody
      • POMC antibody
      • Proopiomelanocortin antibody

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (4)

    发表研究结果有使用 ab54205？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab54205 被引用在 4 文献中.

    • Lau BK  et al. Mu-Opioids Suppress GABAergic Synaptic Transmission onto Orbitofrontal Cortex Pyramidal Neurons with Subregional Selectivity. J Neurosci 40:5894-5907 (2020). PubMed: 32601247
    • Dees WL  et al. Regulation of prepubertal dynorphin secretion in the medial basal hypothalamus of the female rat. J Neuroendocrinol 31:e12810 (2019). PubMed: 31715027
    • Ranganathan S  et al. Molecular interpretation of ACTH-ß-endorphin coaggregation: relevance to secretory granule biogenesis. PLoS One 7:e31924 (2012). IHC-Fr ; Rat . PubMed: 22403619
    • Ubuka T  et al. Gonadotropin-inhibitory hormone identification, cDNA cloning, and distribution in rhesus macaque brain. J Comp Neurol 517:841-55 (2009). ICC/IF ; Macaque monkey . PubMed: 19844991

    客户评价及客户问答

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    1-2 of 2 Abreviews or Q&A

    Question

    Please send a testing discount code for rat, an untested species.

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    Answer

    Discount code: ******** I am very pleased to hear you would like to accept our offer and test ab54205 on rat samples. This code will give you 1 free primary antibody before the expiration date. To redeem this offer, please submit an Abreview for rat data and include this code in the “Additional Comments” section so we know the Abreview is for this promotion. For more information on how to submit an Abreview, please visit the site: www.abcam.com/Abreviews. We publish both positive and negative Abreviews on our datasheets so please submit the results of your tests regardless of the results. The code will be active once the Abreview has been submitted and can be redeemed in one of the following ways: 1) Call to place your order and mention the code to our customer service department; 2) Include the code in your fax order; 3) Place your order on the web and enter the promotional code. Any feedback that you can provide will be greatly appreciated, whether positive or negative. If you have any further questions, please do not hesitate to contact us. We look forward to receiving your Abreview and wish you luck with your research. The terms and conditions applicable to this offer can be found here: www.abcam.com/collaborationdiscount.  

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    Question

    We would like to know some details for the antibody before we purchase it.  does this antibody cross react with its prohormone, proopiomelanocortin (POMC).  Do you have any data on it.

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    Answer

    Thank you for your question about our beta Endorphin antibody, ab54205. We have the same clone, B31.15, listed under a different product identifier, ab1419. The title of a reference listed on the datasheet of that product suggests that the clone will recognize POMC, but I have not confirmed. beta Endorphin antibody [B31.15] (ab1419) Click here (or use the following: https://www.abcam.com/beta-Endorphin-antibody-B3115-ab1419.html). Detection of mRNA transcripts of truncated opiate precursor (POMC) in human cartilage. Andjelkov N et al. Cell Biochem Funct. 2006 May-Jun;24(3):229-35. http://www.ncbi.nlm.nih.gov/pubmed/15898126?dopt=Abstract The antibody is raised against beta endorphin, but it is not clear if the epitope that it recognizes is unique to beta enodrphin, or is also present on POMC. I hope the reference is useful. If you have any questions, please contact us.

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