Anti-beta 2 Microglobulin抗体(ab223571)
Key features and details
- Goat polyclonal to beta 2 Microglobulin
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-beta 2 Microglobulin抗体
参阅全部 beta 2 Microglobulin 一抗 -
描述
山羊多克隆抗体to beta 2 Microglobulin -
宿主
Goat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Cow, Chimpanzee, Cynomolgus monkey, Rhesus monkey, Gorilla
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免疫原
Synthetic peptide corresponding to Human beta 2 Microglobulin aa 1-100 (N terminal) (Cysteine residue). (NP_004039.1).
Database link: P61769 -
阳性对照
- WB: Human duodenum lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, Tris buffered saline -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
ab223571 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab223571于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 12 kDa (predicted molecular weight: 14 kDa).
1 hour primary incubation is recommended for this product. |
| 说明 |
|---|
|
WB
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 12 kDa (predicted molecular weight: 14 kDa). 1 hour primary incubation is recommended for this product. |
靶标
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功能
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. -
疾病相关
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. -
序列相似性
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain. -
翻译后修饰
Glycation of Ile-21 is observed in long-term hemodialysis patients. -
细胞定位
Secreted. Detected in serum and urine. - Information by UniProt
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数据库链接
- Entrez Gene: 450170 Chimpanzee
- Entrez Gene: 280729 Cow
- Entrez Gene: 101867173 Cynomolgus monkey
- Entrez Gene: 101132159 Gorilla
- Entrez Gene: 567 Human
- Entrez Gene: 712428 Rhesus monkey
- Omim: 109700 Human
- SwissProt: P61770 Chimpanzee
see all -
别名
- B2M antibody
- B2MG_HUMAN antibody
- Beta 2 microglobin antibody
see all
图片
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Western blot - Anti-beta 2 Microglobulin antibody (ab223571)Anti-beta 2 Microglobulin antibody (ab223571) at 0.3 µg/ml + human duodenum lysate (in RIPA buffer) at 35 µg
Developed using the ECL technique.
Predicted band size: 14 kDa
Observed band size: 12 kDa why is the actual band size different from the predicted?Primary incubation was 1 hour.
数据表及文件
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Datasheet download
文献 (0)
ab223571 尚未被引用在任何文献中。
