Anti-beta 2 Microglobulin抗体[3F9-2C2] (ab54810)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta 2 Microglobulin antibody [3F9-2C2] (ab54810)](https://www.abcam.cn/ps/products/54/ab54810/Images/ab54810-67864-anti-beta-2-microglobulin-antibody-immunohistochemistry.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta 2 Microglobulin antibody [3F9-2C2] (ab54810)")
Key features and details
- Mouse monoclonal [3F9-2C2] to beta 2 Microglobulin
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG2b
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-beta 2 Microglobulin抗体[3F9-2C2]
参阅全部 beta 2 Microglobulin 一抗 -
描述
小鼠单克隆抗体[3F9-2C2] to beta 2 Microglobulin -
宿主
Mouse -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein, corresponding to amino acids 1-120 of Human beta 2 Microglobulin
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常规说明
This product was changed from ascites to tissue culture supernatant on 22/03/2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.4 -
Concentration information loading... -
纯度
Tissue culture supernatant -
克隆
单克隆 -
克隆编号
3F9-2C2 -
同种型
IgG2b -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab54810于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use at an assay dependent concentration. Predicted molecular weight: 14 kDa.
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| IHC-P |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
WB
Use at an assay dependent concentration. Predicted molecular weight: 14 kDa. |
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IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. -
疾病相关
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. -
序列相似性
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain. -
翻译后修饰
Glycation of Ile-21 is observed in long-term hemodialysis patients. -
细胞定位
Secreted. Detected in serum and urine. - Information by UniProt
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数据库链接
- Entrez Gene: 567 Human
- Omim: 109700 Human
- SwissProt: P61769 Human
- Unigene: 534255 Human
- Unigene: 702947 Human
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别名
- B2M antibody
- B2MG_HUMAN antibody
- Beta 2 microglobin antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta 2 Microglobulin antibody [3F9-2C2] (ab54810)
beta 2 Microglobulin antibody (ab54810) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human esophagus.
This image was generated using the ascites version of the product.
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![Western blot - Anti-beta 2 Microglobulin antibody [3F9-2C2] (ab54810)](https://www.abcam.cn/ps/products/54/ab54810/Images/ab54810-67863-anti-beta-2-microglobulin-antibody-western-blot.jpg)
Western blot - Anti-beta 2 Microglobulin antibody [3F9-2C2] (ab54810)beta 2 Microglobulin antibody (ab54810) at 1ug/lane + U-2 cell lysate at 25ug/lane.
This image was generated using the ascites version of the product.
数据表及文件
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Datasheet download
文献 (2)
ab54810 被引用在 2 文献中.
- Diller M et al. The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts. Arthritis Res Ther 21:144 (2019). PubMed: 31182152
- Wang J et al. Mesenchymal Stromal Cells-Derived ß2-Microglobulin Promotes Epithelial-Mesenchymal Transition of Esophageal Squamous Cell Carcinoma Cells. Sci Rep 8:5422 (2018). PubMed: 29615660
