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AB27780

Anti-Bcl3 抗体

Anti-Bcl3 antibody

1

(2 Reviews)

|

(4 Publications)

Rabbit Polyclonal BCL3 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human BCL3.

查看别名

BCL4, D19S37, BCL3, B-cell lymphoma 3 protein, BCL-3, Proto-oncogene BCL3

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

Synthetic Peptide within Human BCL3. The exact immunogen used to generate this antibody is proprietary information.

P20749

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替代产品

Primary Antibodies

AB15046

Anti-Bcl3 antibody [Ham150-3.5]

Flow Cytometry - Anti-Bcl3 antibody [Ham150-3.5] (AB15046)

  • 0
  • 0
Primary Antibodies

AB216877

Anti-Bcl3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Bcl3 antibody (AB216877)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB8227

Anti-beta Actin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-beta Actin antibody - Loading Control (AB8227)

  • 5
  • 104
Primary Antibodies

AB177487

Anti-NeuN antibody [EPR12763] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Frozen sections) - Anti-NeuN antibody [EPR12763] - Neuronal Marker (AB177487)

  • 5
  • 74
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-4 µg/mL", "WB-species-notes": "<p></p>" } } }
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产品详情

This product is manufactured by BioVision, an Abcam company and was previously called 3407 Bcl-3 Antibody. 3407-100 is the same size as the 100 μg size of ab27780.
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
纯化说明
Affinity purified
存储溶液
pH: 7.2 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Bcl3 protein also known as Bcl-3 is a member of the IκB family of proteins. It serves a mechanical role as a transcription coactivator that interacts with NF-κB p50 and p52 homodimers. The Bcl3 protein has a molecular weight of approximately 45 kDa. This protein expresses primarily in lymphoid tissues including spleen and lymph nodes usually found within the nucleus where it performs its function in regulating gene expression.
Biological function summary

Bcl3 interacts with specific components of the NF-κB complex and modulates signaling pathways involved in immune responses inflammation and cell proliferation. Bcl3 helps in the stabilization and activation of p50/p52 dimers which facilitate the transcription of target genes. Its role necessitates its function within larger complexes that are essential for transcriptional regulation. Bcl3's interaction with other transcription factors allows it to fine-tune the expression of a range of genes impacting several cellular processes.

Pathways

Bcl3 plays a significant role in the regulation of the NF-κB signaling pathway. It acts by modulating the activity of NF-κB dimers important for immune response and inflammation. Furthermore it affects the PI3K/Akt pathway by influencing the expression of genes that are relevant to cell survival and apoptosis. Proteins such as p50 and p52 in the NF-κB pathway closely relate to Bcl3 function highlighting its role in cellular signaling networks.

Bcl3 is linked to certain types of cancers and autoimmune diseases. Its abnormal expression associates with disorders like chronic lymphocytic leukemia where it may contribute to disease progression by affecting cell proliferation and survival. Bcl3's interaction with NF-κB components can also influence rheumatoid arthritis where it might play a part in exacerbating inflammation. Proteins such as p50 and other NF-κB pathway components connect Bcl3 to these diseases reflecting its importance in disease mechanisms.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
See full target information BCL3
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of gastric cancer 20:95-105 PubMed32269848

2020

The Influence of Bcl-3 Expression on Cell Migration and Chemosensitivity of Gastric Cancer Cells via Regulating Hypoxia-Induced Protective Autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Hu,Zhigang Bai,Xuemei Ma,Nan Bai,Zhongtao Zhang

Journal of cellular and molecular medicine 24:202-213 PubMed31668012

2019

Knockdown of long non-coding RNA LINC00176 suppresses ovarian cancer progression by BCL3-mediated down-regulation of ceruloplasmin.

Applications

Unspecified application

Species

Unspecified reactive species

Lan Dai,Jixiang Niu,Yanli Feng

Molecular medicine reports 17:4832-4838 PubMed29328450

2018

MYBL2 protects against H9c2 injury induced by hypoxia via AKT and NF‑κB pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Mingfeng Shao,Zexiang Ren,Rongjun Zhang

Brazilian journal of medical and biological resear 50:e5861 PubMed28355355

2017

CIRBP protects H9C2 cells against myocardial ischemia through inhibition of NF-κB pathway.

Applications

Unspecified application

Species

Unspecified reactive species

T Y Long,R Jing,F Kuang,L Huang,Z X Qian,T L Yang
View all publications
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