Anti-Bassoon/BSN抗体(ab110426)
Key features and details
- Rabbit polyclonal to Bassoon/BSN
- Suitable for: IHC-Fr, IHC-P, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-Bassoon/BSN抗体
参阅全部 Bassoon/BSN 一抗 -
描述
兔多克隆抗体to Bassoon/BSN -
宿主
Rabbit -
特异性
No cross-reactivity to Piccolo. Multiple isoforms can be detected. -
经测试应用
适用于: IHC-Fr, IHC-P, WBmore details -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Fusion protein (His-tag) corresponding to Human Bassoon/BSN aa 750-1050 (N terminal). N-terminal his-tagged fusion protein
Database link: Q9UPA5 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
Preservative: 0.09% Sodium azide
Constituents: PBS, 50% Glycerol -
Concentration information loading... -
纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab110426于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
|
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| IHC-P |
Use at an assay dependent concentration.
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| WB |
1/1000. Predicted molecular weight: 416 kDa. For large isoforms reduce dilution.
|
| 说明 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
|
IHC-P
Use at an assay dependent concentration. |
|
WB
1/1000. Predicted molecular weight: 416 kDa. For large isoforms reduce dilution. |
靶标
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功能
Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses. -
组织特异性
Exclusively expressed in brain. -
翻译后修饰
Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization. -
细胞定位
Cytoplasm. Cell junction > synapse > synaptosome. Cytoplasm > cytoskeleton. Localized to the active zone of presynaptic density. - Information by UniProt
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数据库链接
- Entrez Gene: 8927 Human
- Entrez Gene: 12217 Mouse
- Entrez Gene: 29138 Rat
- Omim: 604020 Human
- SwissProt: Q9UPA5 Human
- SwissProt: O88737 Mouse
- SwissProt: O88778 Rat
- Unigene: 194684 Human
see all -
别名
- Bassoon protein antibody
- bsn antibody
- BSN_HUMAN antibody
see all
图片
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Western blot - Anti-Bassoon/BSN antibody (ab110426)All lanes : Anti-Bassoon/BSN antibody (ab110426) at 1/1000 dilution
Lane 1 : Rat brain lysate
Lane 2 : Mouse brain lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 416 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bassoon/BSN antibody (ab110426)Immunofluorescence of Neuromuscular junction whole muscle samples from adult mouse, stained with ab110426 at 1/400 dilution. Secondary (Alexa 488 goat antimouse IgG, IgM (H+L). Note: bright staining of the NMJ very selectively and in some terminals, very brightly.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab110426 被引用在 2 文献中.
- Chen ZS et al. Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD. Nat Commun 14:8420 (2023). PubMed: 38110419
- Guo N et al. Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization. Nat Med 24:438-449 (2018). PubMed: 29529016