Anti-BAFF-R抗体(ab5965)
Key features and details
- Rabbit polyclonal to BAFF-R
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-BAFF-R抗体
参阅全部 BAFF-R 一抗 -
描述
兔多克隆抗体to BAFF-R -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide corresponding to Human BAFF-R (C terminal).
(Peptide available asab6086) -
阳性对照
- WB: Human, Mouse or Rat spleen tissue lysate. IHC: human lymphoid tissue (see review), human tonsil tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C. Avoid freeze / thaw cycle. Stable for 12 months at -20°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
BAFF-R Antibody is affinity chromatography purified via peptide column. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 19 kDa.
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IHC-P |
1/1000 - 1/2000.
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说明 |
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WB
Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 19 kDa. |
IHC-P
1/1000 - 1/2000. |
靶标
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功能
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. -
组织特异性
Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. -
疾病相关
Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. -
序列相似性
Contains 1 TNFR-Cys repeat. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 115650 Human
- Entrez Gene: 72049 Mouse
- Entrez Gene: 500910 Rat
- Omim: 606269 Human
- SwissProt: Q96RJ3 Human
- SwissProt: Q9D8D0 Mouse
- Unigene: 344088 Human
- Unigene: 240047 Mouse
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别名
- B cell activating factor receptor antibody
- B-cell-activating factor receptor antibody
- BAFF R antibody
see all
图片
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Western blot analysis of BAFF-R in human (H), mouse (M), and rat (R) spleen tissue lysates with ab5965 at 5 µg/ml.
Western blot analysis of BAFF-R in human (H), mouse (M), and rat (R) spleen tissue lysates with ab5965 at 5 µg/ml.
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Immunohistochemistry (Formalin-fixed paraffin embedded sections) of human spleen tissue labeling BAFF-R with Anti-BAFF-R antibody (ab5965) at 20μg/ml.
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Immunohistochemistry of BAFF-R in human spleen tissue with BAFF-R antibody at 5 µg/ml.
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Immunohistochemistry (formalin-fixed paraffin-embedded) of BAFF-R in human tonsil tissue with ab5965 at 5 ug/ml.
数据表及文件
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Datasheet download
文献 (9)
ab5965 被引用在 9 文献中.
- Zhan T et al. Artesunate inhibits Sjögren's syndrome-like autoimmune responses and BAFF-induced B cell hyperactivation via TRAF6-mediated NF-?B signaling. Phytomedicine 80:153381 (2021). PubMed: 33086170
- Cao Y et al. BAFF is involved in the pathogenesis of IgA nephropathy by activating the TRAF6/NF-?B signaling pathway in glomerular mesangial cells. Mol Med Rep 21:795-805 (2020). PubMed: 31974601
- Zhao Y et al. Factors associated with refractory autoimmune necrotizing myopathy with anti-signal recognition particle antibodies. Orphanet J Rare Dis 15:181 (2020). PubMed: 32641139
- Ma S et al. microRNA-96 promotes osteoblast differentiation and bone formation in ankylosing spondylitis mice through activating the Wnt signaling pathway by binding to SOST. J Cell Biochem 120:15429-15442 (2019). PubMed: 31111563
- Ramani B et al. Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes. Hum Mol Genet 26:3362-3374 (2017). PubMed: 28854700
- Price JV et al. Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. J Clin Invest 123:5135-45 (2013). PubMed: 24270423
- Birnbaum T et al. Expression of B-cell activating factor, a proliferating inducing ligand and its receptors in primary central nervous system lymphoma. Neurol Int 5:e4 (2013). PubMed: 23717783
- Hildebrand JM et al. A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling. J Exp Med 207:2569-79 (2010). WB ; Human . PubMed: 21041452
- Paterson JC et al. The differential expression of LCK and BAFF-receptor and their role in apoptosis in human lymphomas. Haematologica 91:772-80 (2006). WB, IHC-P ; Human . PubMed: 16769579