AB177736

Anti-B3GALT2抗体

Name: B3GALT2抗体 (ab177736)| Abcam中文官网
Brand: Abcam Limited
SKU: AB177736
Price: 4606 CNY
Availability: InStock

Anti-B3GALT2 antibody

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(1 Publication)

Rabbit Polyclonal B3GALT2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human B3GALT2.

查看别名

Beta3Gal-T2, Beta3GalT2, UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2, B3GALT2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B3GALT2 antibody (AB177736)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B3GALT2 antibody (AB177736)

Immunohistochemical analysis of paraffin-embedded Human heart tissue labeling B3GALT2 with ab177736 at 1/50 dilution (left panel). The right panel is with blocking peptide.

Immunocytochemistry/ Immunofluorescence - Anti-B3GALT2 antibody (AB177736)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-B3GALT2 antibody (AB177736)

Immunofluorescent analysis of A549 cells labeling B3GALT2 with ab177736 at 1/100 dilution (left panel). The right panel is with blocking peptide.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, IHC-P

applications

免疫原

Synthetic Peptide within Human B3GALT2. The exact immunogen used to generate this antibody is proprietary information.

O43825

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab177736 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

存储溶液

pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

B3GALT2 also known as Beta-13-galactosyltransferase 2 is an enzyme with a molecular weight of approximately 43 kDa. This protein mostly functions within the Golgi apparatus where it facilitates carbohydrate biosynthesis. The enzyme adds galactose in a beta-13 linkage to N-acetylglucosamine residues on glycoproteins and glycolipids. Expression of B3GALT2 occurs widely across tissues with notable levels in the liver and kidney.

Biological function summary

B3GALT2 plays a role in the biosynthesis of glycoproteins and glycolipids. These processes are essential for cell-cell communication and molecular stability on the cell surface. The enzyme operates as a part of the larger family of glycosyltransferases. It does not typically form complexes functioning independently to carry out its catalytic activities within cells. The resulting glycan structures contribute significantly to maintaining cellular homeostasis and signaling mechanisms.

Pathways

The regulation of cell surface glycosylation requires the involvement of B3GALT2. It is actively engaged in pathways such as N-glycan biosynthesis and the formation of glycosphingolipids. B3GALT2 works in coordination with other glycosyltransferases like ST3GAL1 to ensure the correct assembly of glycan chains. These pathways directly influence processes like cell adhesion and immune response modulation.

Abnormalities in B3GALT2 expression relate to conditions such as congenital disorders of glycosylation and certain kidney diseases. Altered enzymatic activity can lead to improper glycosylation patterns affecting protein function and stability. In these disorders B3GALT2 might have interactions with proteins involved in endoplasmic reticulum-associated degradation playing a role in the molecular pathology observed in affected cells.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.

See full target information B3GALT2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular neurobiology 43:1957-1974 PubMed36006573

2022

Mild Hypothermia Alleviates Complement C5a-Induced Neuronal Autophagy During Brain Ischemia-Reperfusion Injury After Cardiac Arrest.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Wang,Yuanyuan Sun,Fang Kong,Yi Jiang,Mengmeng An,Beibei Jin,Da Cao,Ruifang Li,Xiaolan Guan,Shuangshuang Liang,Subi Abudurexiti,Ping Gong

View all publications

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Abcam Product Promise

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Anti-B3GALT2抗体

Anti-B3GALT2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B3GALT2 antibody (AB177736)

Immunocytochemistry/ Immunofluorescence - Anti-B3GALT2 antibody (AB177736)