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AB122437

Anti-ATRNL1抗体

Anti-ATRNL1 antibody

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(1 Publication)

Rabbit Polyclonal ATRNL1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATRNL1 aa 800-950.

查看别名

KIAA0534, ATRNL1, Attractin-like protein 1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATRNL1 antibody (AB122437)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATRNL1 antibody (AB122437)

ab122437, at a 1/20 dilution, staining ATRNL1 in paraffin embedded Human small intestine tissue by Immunohistochemistry.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human ATRNL1 aa 800-950. The exact immunogen used to generate this antibody is proprietary information.

Q5VV63

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ATRNL1 also known as Attractin-like 1 is a protein involved in cell signaling and communication. The protein weighs approximately 151 kDa. It is expressed in several tissues including the central nervous system and some peripheral tissues. ATRNL1 is part of a family of proteins that include Attractin and shares structural similarities with proteins involved in neuroendocrine functions.
Biological function summary

ATRNL1 plays a role in cell growth and differentiation influencing neural development. It does not seem to form part of a known protein complex but influences signaling pathways critical for neurodevelopment. Researchers have shown interest in its function in brain regions where neurogenesis and neuron differentiation occur.

Pathways

ATRNL1 is involved in the neurotrophin signaling pathway critical for neuronal survival and differentiation. It shares connections with neurotrophic proteins like NGF and BDNF in these pathways. ATRNL1 influences neuroplasticity through regulating the availability of these neurotrophins thereby modulating cellular responses downstream in neural tissues.

ATRNL1 has been studied in relation to neurodevelopmental disorders and neurodegenerative diseases. In autism spectrum disorders ATRNL1 may influence neuron connectivity and signaling through interactions with regulatory proteins like MECP2. Additionally its altered expression has been noted in Alzheimer’s disease where it may impact amyloid-beta homeostasis alongside proteins such as APP suggesting potential involvement in neural degeneration.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

May play a role in melanocortin signaling pathways that regulate energy homeostasis.
See full target information ATRNL1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 35:65-73 PubMed30715488

2019

Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia.

Applications

Unspecified application

Species

Unspecified reactive species

Nadine Kaesler,Claudia Goettsch,Daniel Weis,Leon Schurgers,Burkhard Hellmann,Jürgen Floege,Rafael Kramann
View all publications
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