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AB182626

Anti-ATRIP (phospho S68)抗体

Anti-ATRIP (phospho S68) antibody

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Rabbit Polyclonal ATRIP phospho S68 antibody. Suitable for WB and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human ATRIP phospho S68 aa 50-100 conjugated to Keyhole Limpet Haemocyanin.

查看别名

AGS1, ATRIP, ATR-interacting protein, ATM and Rad3-related-interacting protein

1 Images
Western blot - Anti-ATRIP (phospho S68) antibody (AB182626)
  • WB

Supplier Data

Western blot - Anti-ATRIP (phospho S68) antibody (AB182626)

All lanes:

Western blot - Anti-ATRIP (phospho S68) antibody (ab182626) at 1/500 dilution

Lane 1:

Extracts from 3T3 cells with Antigen-specific peptide

Lane 2:

Extracts from 3T3 cells

Predicted band size: 86 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse

应用

WB

applications

免疫原

Synthetic Peptide within Human ATRIP phospho S68 aa 50-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8WXE1

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
纯化说明
Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.
存储溶液
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ATRIP also known as ATRIP protein serves as an essential component within the ATR-ATRIP complex which is vital in the DNA damage response. ATRIP is a protein that weighs approximately 86 kDa and is most commonly expressed in the nucleus of cells. It functions primarily by binding to ATR (Ataxia Telangiectasia and Rad3-related protein) which enables the ATR to localize to sites of DNA damage and replication stress. This enables the recognition and repair of damaged DNA preventing genomic instability.
Biological function summary

ATRIP plays roles in maintaining genome integrity. It forms a stable complex with ATR which is important for the activation of ATR kinase activity. ATRIP directly interacts with single-stranded DNA coated by replication protein A (RPA) to perform its functions. By facilitating ATR recruitment to DNA damage sites ATRIP aids in the initiation of DNA repair mechanisms which are critical for normal cellular function and survival.

Pathways

ATRIP's activities are an integral part of the DNA damage signaling and repair pathways. ATR-ATRIP complex is central to the DNA replication checkpoint pathway where it maintains replication fork stability and controls cell cycle progression. Additionally ATRIP is involved in pathways alongside proteins like CHK1 which it helps to activate in response to DNA damage ensuring proper cell cycle arrest and repair processes.

ATRIP is implicated in certain cancers and genomic instability syndromes. Deficient ATRIP function can correlate with a higher predisposition to cancers due to defective DNA damage response and repair. Further the ATR-ATRIP interaction can influence the onset and progression of Seckel syndrome where defects in ATRIP or its partner ATR might lead to developmental abnormalities. The role of ATRIP in these diseases highlights the importance of maintaining genomic stability through effective DNA repair mechanisms.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
See full target information ATRIP phospho S68
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Abcam Product Promise

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详情请参阅我们的条款与条件。
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