Anti-ATP6AP1/ATP6S1抗体(ab176609)
Key features and details
- Rabbit polyclonal to ATP6AP1/ATP6S1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ATP6AP1/ATP6S1抗体 -
描述
兔多克隆抗体to ATP6AP1/ATP6S1 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
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免疫原
Recombinant fragment corresponding to Human ATP6AP1/ATP6S1 aa 44-235.
Sequence:QVPLVLW SSDRDLWAPA ADTHEGHITS DLQLSTYLDP ALELGPRNVL LFLQDKLSIE DFTAYGGVFG NKQDSAFSNL ENALDLAPSS LVLPAVDWYA VSTLTTYLQE KLGASPLHVD LATLRELKLN ASLPALLLIR LPYTASSGLM APREVLTGND EVIGQVLSTL KSEDVPYTAA LTAVRPSRVA RDVAV
Database link: Q15904 -
阳性对照
- Fetal kidney lysate, human brain tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:200 ul distilled water -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab176609于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/200 - 1/1000. Predicted molecular weight: 52 kDa.
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| IHC-P |
1/100 - 1/500.
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| 说明 |
|---|
|
WB
1/200 - 1/1000. Predicted molecular weight: 52 kDa. |
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IHC-P
1/100 - 1/500. |
靶标
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相关性
ATP6AP1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme, which is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. V-ATPase dependent organelle acidification is necessary for intracellular processes such as receptor-mediated endocytosis, protein sorting and zymogen activation. -
细胞定位
Vacuole membrane. Single-pass membrane protein. -
数据库链接
- Entrez Gene: 537 Human
- Entrez Gene: 54411 Mouse
- Entrez Gene: 83615 Rat
- Omim: 300197 Human
- SwissProt: Q15904 Human
- SwissProt: Q9R1Q9 Mouse
- SwissProt: O54715 Rat
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别名
- 16A antibody
- Ac45 antibody
- ATP6IP1 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP6AP1/ATP6S1 antibody (ab176609)
Immunohistochemical staining of formalin-fixed paraffin-embedded Human brain tissue labeling ATP6AP1/ATP6S1 with ab176609 at 1/100 dilution showing membrane staining.
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Western blot - Anti-ATP6AP1/ATP6S1 antibody (ab176609)Anti-ATP6AP1/ATP6S1 antibody (ab176609) at 1/500 dilution + Fetal kidney lysate
Predicted band size: 52 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab176609 被引用在 3 文献中.
- Ma T et al. Low-dose metformin targets the lysosomal AMPK pathway through PEN2. Nature 603:159-165 (2022). PubMed: 35197629
- Sun X et al. SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1. Cell Death Differ 29:1240-1254 (2022). PubMed: 34997207
- Rujano MA et al. Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects. J Exp Med 214:3707-3729 (2017). PubMed: 29127204