Anti-ATP2C1抗体(ab126171)
Key features and details
- Rabbit polyclonal to ATP2C1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ATP2C1抗体
参阅全部 ATP2C1 一抗 -
描述
兔多克隆抗体to ATP2C1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Cow
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免疫原
Recombinant fragment, corresponding to a region within internal sequence amino acids 483-721 of Human ATP2C1 (UniProt P98194).
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阳性对照
- HeLa whole cell lysate; A549 cell lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab126171于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/3000. Predicted molecular weight: 101 kDa.
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| 说明 |
|---|
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WB
1/500 - 1/3000. Predicted molecular weight: 101 kDa. |
靶标
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功能
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. -
组织特异性
Found in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney. -
疾病相关
Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD) [MIM:169600]; also known as benign familial pemphigus. HHD is an autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD. -
序列相似性
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. -
细胞定位
Golgi apparatus membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 27032 Human
- Entrez Gene: 235574 Mouse
- Entrez Gene: 170699 Rat
- Omim: 604384 Human
- SwissProt: P98194 Human
- SwissProt: Q80XR2 Mouse
- SwissProt: Q64566 Rat
- Unigene: 584884 Human
see all -
别名
- 1700121J11Rik antibody
- AT2C1_HUMAN antibody
- ATP dependent Ca(2+) pump PMR1 antibody
see all
图片
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Western blot - Anti-ATP2C1 antibody (ab126171)Anti-ATP2C1 antibody (ab126171) at 1/2000 dilution + HeLa whole cell lysate at 30 µg
Predicted band size: 101 kDa
7.5% SDS PAGE
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab126171 被引用在 2 文献中.
- He J et al. OM-MSCs Alleviate the Golgi Apparatus Stress Response following Cerebral Ischemia/Reperfusion Injury via the PEDF-PI3K/Akt/mTOR Signaling Pathway. Oxid Med Cell Longev 2021:4805040 (2021). PubMed: 34815829
- He J et al. Olfactory Mucosa Mesenchymal Stem Cells Alleviate Cerebral Ischemia/Reperfusion Injury Via Golgi Apparatus Secretory Pathway Ca2+ -ATPase Isoform1. Front Cell Dev Biol 8:586541 (2020). PubMed: 33195239