AB201108

Anti-ATP synthase C抗体

Name: ATP synthase C抗体 (ab201108)| Abcam中文官网
Brand: Abcam Limited
SKU: AB201108

Anti-ATP synthase C antibody

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(1 Publication)

Rabbit Polyclonal ATP synthase C antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATP5MC1 aa 1-100.

查看别名

ATP5G1, ATP5MC1, ATP synthase lipid-binding protein, ATP synthase membrane subunit c locus 1, ATP synthase proteolipid P1, ATP synthase proton-transporting mitochondrial F(0) complex subunit C1, ATPase protein 9, ATPase subunit c

1 Images

Supplier Data

Western blot - Anti-ATP synthase C antibody (AB201108)

All lanes:

Western blot - Anti-ATP synthase C antibody (ab201108)

Lane 1:

HEK293T whole cell lysate

Lane 2:

Raw264.7 whole cell lysate

Lane 3:

H9C2 whole cell lysate

Predicted band size: 14 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat, Human

应用

applications

免疫原

Synthetic Peptide within Human ATP5MC1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P05496

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

Purity is > 95% (by SDS-PAGE).

存储溶液

pH: 7.3 Preservative: 0.05% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ATP synthase subunit c also known as ATP synthase C ATP-C or ATP synthase C subunit is an integral component of the ATP synthase complex. This protein has a known molecular mass of approximately 8.3 kDa. It is prominently expressed in mitochondrial membranes where it serves as an important part of the proton channel. Its primary function involves facilitating the conversion of proton motive force into rotational mechanical energy which drives ATP synthesis. Through this mechanical action ATP synthase C contributes significantly to energy conversion within cells.

Biological function summary

ATP synthase C functions as a critical component of the ATP synthase enzyme complex also known as FoF1 ATPase or Complex V of the oxidative phosphorylation pathway. This subunit forms a ring structure that allows protons to move across the mitochondrial membrane which is necessary for the synthesis of ATP from ADP and inorganic phosphate. By participating in this synthesis process ATP synthase C impacts cellular energy metabolism affecting various physiological functions dependent on ATP as an energy source.

Pathways

ATP synthase C plays an essential role within the oxidative phosphorylation pathway. This pathway is integral to cellular respiration and is responsible for the majority of ATP production in aerobic organisms. ATP synthase C interacts with other proteins such as the ATP synthase alpha and beta subunits which form the catalytic core of the enzyme. These interactions are central to the energy currency of the cell ensuring efficient energy conversion and transfer.

ATP synthase C is implicated in mitochondrial dysfunctions and associated conditions such as mitochondrial myopathies and neurodegenerative diseases. Mitochondrial myopathies result from defects in the oxidative phosphorylation pathway often involving proteins like cytochrome c oxidase which are important for efficient ATP production. Disorders related to ATP synthase C dysfunction can cause significant impacts on tissues that require high energy reflecting its critical role in maintaining cellular energy balance.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

See full target information ATP5MC1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:20196 PubMed39215036

2024

Lymphocyte antigen 6 family member E suppresses apoptosis and promotes pancreatic cancer growth and migration via Wnt/β-catenin pathway activation.

Applications

Unspecified application

Species

Unspecified reactive species

Kenan Cen,Jingyao Zhou,Xuejia Yang,Yangyang Guo,Yanyi Xiao

View all publications

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Anti-ATP synthase C抗体

Anti-ATP synthase C antibody

Western blot - Anti-ATP synthase C antibody (AB201108)