Anti-ATG8 抗体

靶点信息

Ubiquitin-like modifier involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosome formation (PubMed : 10525546, PubMed : 10681575, PubMed : 10837468, PubMed : 11038174, PubMed : 11149920, PubMed : 16680092, PubMed : 18508918, PubMed : 19398890, PubMed : 21429936, PubMed : 7593182, PubMed : 8224160). With ATG4, mediates the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton (PubMed : 9649430). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed : 17404498, PubMed : 22768199). Participates also in membrane fusion events that take place in the early secretory pathway (PubMed : 10837468). Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (PubMed : 17132049). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (PubMed : 11100732, PubMed : 17632063, PubMed : 20855502). Moreover not only conjugation, but also subsequent ATG8-PE deconjugation is an important step required to facilitate multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components (PubMed : 17632063, PubMed : 20855502, PubMed : 22622160). Also plays a role in regulation of filamentous growth (PubMed : 17700056).. Has a lipidation-independent vacuolar function to facilitate the degradation of vacuolar integral membrane proteins during early-stationary vacuole turnover (EVT) when cells enter stationary phase.