AB112563

Anti-ATAD3B抗体

Name: ATAD3B抗体 (ab112563)| Abcam中文官网
Brand: Abcam Limited
SKU: AB112563
Price: 4606 CNY
Availability: InStock

Anti-ATAD3B antibody

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(1 Publication)

Rabbit Polyclonal ATAD3B antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATAD3B.

查看别名

KIAA1273, TOB3, ATAD3B, ATPase family AAA domain-containing protein 3B, AAA-TOB3

2 Images

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Immunocytochemistry - Anti-ATAD3B antibody (AB112563)

Immunohistochemistry of ATAD3B in human kidney tissue with ab112563 at 5 ug/mL.

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Western blot - Anti-ATAD3B antibody (AB112563)

Lane 1:

Western blot - Anti-ATAD3B antibody (ab112563) at 1 µg/mL

Lane 2:

Western blot - Anti-ATAD3B antibody (ab112563) at 2 µg/mL

All lanes:

Human kidney tissue lysate at 15 µg

Predicted band size: 72 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, ICC

applications

免疫原

Synthetic Peptide within Human ATAD3B. The exact immunogen used to generate this antibody is proprietary information.

Q5T9A4

特异性

ab112563 is predicted to not cross-react with other ATAD protein family members.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "5 µg/mL", "ICC-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ATAD3B also known as ATPase family AAA domain-containing protein 3B is a mitochondrial membrane protein with a mass of about 67 kDa. You can find ATAD3B expression predominantly in tissues with high energy demands including the brain and muscle. The protein functions mechanically as an ATPase enzyme involved in mitochondrial processes like maintaining mitochondrial DNA and dynamics.

Biological function summary

ATAD3B plays roles in mitochondrial homeostasis and organelle communication. It forms part of a complex machinery within the mitochondria working closely with proteins like ATAD3A. This interaction contributes to the proper arrangement of mitochondrial DNA and protein import ensuring cellular energy management and metabolic functioning remain efficient.

Pathways

ATAD3B contributes to mitochondrial biogenesis and dynamics. It integrates into pathways such as the mitochondrial quality control pathway and mitochondrial fission and fusion processes. Proteins like DRP1 and MFN2 interact with ATAD3B in these pathways influencing the balance and architectural function of the mitochondria within cells.

ATAD3B has links to neurological diseases and certain cancers. Disruptions in the function of ATAD3B correlate with altered mitochondrial dynamics seen in these conditions. Proteins such as ATAD3A and mutations in genes associated with the protein may exacerbate mitochondrial dysfunction emphasizing the importance of proper ATAD3B function in disease prevention and processes.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. May act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.

See full target information ATAD3B

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Infection and immunity 93:e0019425 PubMed40422078

2025

Ficolin-1 in pediatric malaria and its possible role in parasite clearance and anemia.

Applications

Unspecified application

Species

Unspecified reactive species

Di Zheng,Natalie Ferrington,Dilini Rathnayake,Wina Hasang,Agersew Alemu,Visopo Harawa,Amalia Karahalios,Phoebe Fitzpatrick,Evelyne Gout,Nicole M Thielens,Karl Seydel,Terrie E Taylor,Wilson Mandala,Stephen J Rogerson,Elizabeth H Aitken,Louise M Randall

View all publications

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Abcam Product Promise

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Anti-ATAD3B抗体

Anti-ATAD3B antibody

Immunocytochemistry - Anti-ATAD3B antibody (AB112563)

Western blot - Anti-ATAD3B antibody (AB112563)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性