Anti-Aspergillus抗体(ab20419)
Key features and details
- Rabbit polyclonal to Aspergillus
- Suitable for: ELISA, IHC-Fr, IHC-P
- Reacts with: Aspergillus nidulans
- Isotype: IgG
概述
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产品名称
Anti-Aspergillus抗体
参阅全部 Aspergillus 一抗 -
描述
兔多克隆抗体to Aspergillus -
宿主
Rabbit -
经测试应用
适用于: ELISA, IHC-Fr, IHC-Pmore details -
种属反应性
与反应: Aspergillus nidulans -
免疫原
Tissue, cells or virus corresponding to Aspergillus. Soluble extract from A. fumigatus, A. flavus, A. niger and A. terreus.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.1% Sodium azide
Constituent: 0.0268% PBS -
Concentration information loading... -
纯度
Protein A purified -
纯化说明
>95% pure -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab20419于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| IHC-Fr |
Use at an assay dependent concentration.
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| IHC-P |
Use at an assay dependent concentration.
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| 说明 |
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ELISA
Use at an assay dependent concentration. |
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IHC-Fr
Use at an assay dependent concentration. |
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IHC-P
Use at an assay dependent concentration. |
靶标
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相关性
The genus Aspergillus includes over 185 species. Around 20 species have been reported as causative agents of opportunistic infections in humans. Among these, Aspergillus fumigatus is the most commonly isolated species, followed by Aspergillus flavus. Aspergillus fumigatus is the major cause of aspergillosis. This organism causes both invasive and allergic aspergillosis. Aspergillus also produce fungal toxins called mycotoxins. Aflatoxin is produced by Aspergillus flavus as it grows on corn and peanuts. The toxin is poisonous to humans by ingestion and causes liver disease. Aspergillus nidulans can produce the mycotoxin sterigmatocystin. This toxin has been shown to produce liver and kidney damage in lab animals. Aspergillus oschraceus,found in grains, soil and salted food products can produce a kidney toxin called oschratoxin A, which may produce oschratoxicosis in humans. Ochratoxin may also be produced by other aspergillus and penicillium species. Other toxins that can be produced by this fungus include penicillic acid, xanthomegnin and viomellein. Aspergillus infections have a very high mortality rate. Their incidence is growing because of the increased number of immunocompromised patients. Previous to antibodies such as these, special stains were used to identify aspergillus. Aspergillus oryzae and Aspergillus niger are used extensively in industrial scale fermentation to produce enzymes for processing household food and drink products.
图片
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Immunohistochemistry (Frozen sections) - Anti-Aspergillus antibody (ab20419)Image from Grahl N et al., PLoS Pathog. 2011 Jul;7(7):e1002145. Epub 2011 Jul 21. Fig 2.; doi:10.1371/journal.ppat.1002145; July 21, 2011, PLoS Pathog 7(7): e1002145.ab20419, staining Aspergillus (green) in lung tissue from a murine model of corticosteroid-induced invasive pulmonary aspergillosis, by Immunohistochemistry.
Tissue was fixed in cold acetone for 15 min, followed by washing and blocking with normal serum block at RT for 30 min. Sections were incubated overnight at 4°C with primary antibody. An AlexaFluor®488-conjugated goat anti-rabbit IgG (1/00) was used as the secondary antibody. -
Immunohistochemistry (Frozen sections) - Anti-Aspergillus antibody (ab20419)Image from Grahl N et al., PLoS Pathog. 2011 Jul;7(7):e1002145. Epub 2011 Jul 21. Fig 2.; doi:10.1371/journal.ppat.1002145; July 21, 2011, PLoS Pathog 7(7): e1002145.ab20419, staining Aspergillus (green) in lung tissue from a murine model of chemotherapy-induced invasive pulmonary aspergillosis, by Immunohistochemistry.
Tissue was fixed in cold acetone for 15 min, followed by washing and blocking with normal serum block at RT for 30 min. Sections were incubated overnight at 4°C with primary antibody. An AlexaFluor®488-conjugated goat anti-rabbit IgG (1/00) was used as the secondary antibody.
数据表及文件
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SDS download
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Datasheet download
文献 (6)
ab20419 被引用在 6 文献中.
- Narunsky-Haziza L et al. Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions. Cell 185:3789-3806.e17 (2022). PubMed: 36179670
- Keizer EM et al. Variation of virulence of five Aspergillus fumigatus isolates in four different infection models. PLoS One 16:e0252948 (2021). PubMed: 34242260
- Schmidt S et al. The domestic pig as human-relevant large animal model to study adaptive antifungal immune responses against airborne Aspergillus fumigatus. Eur J Immunol 50:1712-1728 (2020). PubMed: 32558930
- Watanabe I et al. Invasive aspergillosis in the aortic arch with infectious Aspergillus lesions in pulmonary bullae. Med Mycol Case Rep 7:15-9 (2015). PubMed: 27330942
- Chang SC et al. Probable Blastomyces dermatitidis Infection in a Young Rat. Vet Pathol : (2012). PubMed: 22711744
- Grahl N et al. In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis. PLoS Pathog 7:e1002145 (2011). IHC-Fr . PubMed: 21811407